MOISTURE ADSORPTION AND EFFECT OF ADSORBED WATER ON THE POWDER AND COMPACTION PROPERTIES OF RANITIDINE HYDROCHLORIDE

被引：0

作者：

UZUNARSLAN, K ^{[1
]}

AKBUGA, J ^{[1
]}

机构：

[1] UNIV MARMARA,FAC PHARM,DEPT PHARMACEUT TECHNOL,BUYUKCIFTLIK SOK 6,NISANTASI 80200,TURKEY

来源：

PHARMAZIE | 1991年 / 46卷 / 04期

关键词：

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Moisture adsorption properties of ranitidine hydrochloride were investigated. The amount of water adsorbed was very small up to 75% relative humidity (RH), however, after this value (critical RH), an abrupt increase was observed in the moisture adsorption. Addition of excipients changed the water uptake levels of drug. Furthermore moisture adsorption proportionally increased with the amount of Avicel(R) and corn starch. In the second part of this study the effect of adsorbed water on powder and compaction properties of ranitidine hydrochloride was studied. The powder and compaction properties of the drug were changed by water adsorption.

引用

页码：273 / 275

页数：3

共 11 条

[1] MOISTURE ADSORPTION AND TABLETTING .1. EFFECT ON VOLUME REDUCTION PROPERTIES AND TABLET STRENGTH FOR SOME CRYSTALLINE MATERIALS [J].

AHLNECK, C ;

ALDERBORN, G .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1989, 54 (02) :131-141

[2]

ARMSTRONG NA, 1970, PHARM ACTA HELV, V45, P692

[3] THE EFFECT OF MOISTURE ON POWDER FLOW AND ON COMPACTION AND PHYSICAL STABILITY OF TABLETS [J].

DAWOODBHAI, S ;

RHODES, CT .

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 1989, 15 (10) :1577-1600

[4]

FUKUOKA E, 1983, CHEM PHARM BULL, V31, P221

[5]

KAWAKITA K, 1970, POWDER TECHNOL, V4, P61

[6]

Nicklasson M, 1982, INT J PHARM TECH PRO, V3, P115

[7]

Nyqvist H, 1983, INT J PHARM TECH PRO, V4, P67

[8]

REES JE, 1972, PHARM ACTA HELV, V47, P235

[9] EFFECT OF MOISTURE ON THE PHYSICAL AND CHEMICAL-STABILITY OF GRANULATIONS AND TABLETS OF THE ANGIOTENSIN CONVERTING-ENZYME-INHIBITOR, ENALAPRIL MALEATE [J].

SHIROMANI, PK ;

BAVITZ, JF .

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 1986, 12 (14) :2467-2480

[10] THE EFFECT OF ADSORBED WATER ON COMPACTION PROPERTIES AND THE DISSOLUTION OF QUINACRINE HYDROCHLORIDE FROM COMPACTED MATRICES OF SOY PROTEIN [J].

TENG, CD ;

ALKAN, MH ;

GROVES, MJ .

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 1986, 12 (11-13) :2325-2336

← 1 2 →