NEU (C-ERBB-2), A TUMOR-MARKER IN CARCINOMA OF THE FEMALE BREAST

被引:0
作者
MAGUIRE, HC
GREENE, MI
机构
关键词
C-ERBB-2; ADENOCARCINOMA; BREAST; CANCER; NEU; TUMOR MARKER; ONCOGENE; DNA AMPLIFICATION; PROGNOSIS;
D O I
暂无
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The c-erbB-2 oncogene encodes a transmembrane phosphoglycoprotein. This molecule appears to be a growth factor receptor in the family of tyrosine kinase growth factor receptors; however, its ligand has not yet been identified. Amplification and/or overexpression of c-erbB-2 in breast adenocarcinomas occurs frequently and its occurrence implies a more advanced malignancy. This functional tumor marker is readily identified by appropriate DNA and antibody probes. The large external domain of the c-erbB-2 gene product is a promising target for immunodiagnostic and immunotherapeutic modalities.
引用
收藏
页码:297 / 303
页数:7
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