BIRTH OF NORMAL YOUNG AFTER ELECTROFUSION OF MOUSE OOCYTES WITH ROUND SPERMATIDS

被引：240

作者：

OGURA, A

MATSUDA, J

YANAGIMACHI, R

机构：

[1] UNIV HAWAII,JOHN A BURNS SCH MED,DEPT ANAT & REPROD BIOL,HONOLULU,HI 96822

[2] JAPANS NATL INST HLTH,DEPT VET SCI,SHINJUKU KU,TOKYO,JAPAN

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1994年 / 91卷 / 16期

关键词：

D O I：

10.1073/pnas.91.16.7460

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Normally, round spermatids, the youngest male germ cells with a set of haploid chromosomes, cannot fertilize mature oocytes. However, when mouse spermatids were fused with oocytes, some of the resulting zygotes developed into normal fertile mice of either sex. This demonstrates that the nuclei of spermatids can provide the paternally imprinted chromosomes needed for full embryonic development and also that the complex postmeiotic modifications involved in sperm formation in the testis and their maturation in the epididymis merely serve to facilitate natural delivery of the paternal genome. This finding may find an application in the treatment of male infertility due to defective spermiogenesis/sperm maturation.

引用

页码：7460 / 7462

页数：3

共 16 条

[1]

AUSTIN CR, 1961, MAMMALIAN EGG, P22

[2]

AUSTIN CR, 1985, BIOL FERTILIZATION, V2, P121

[3]

BARTON SC, 1991, DEVELOPMENT, V113, P679

[4] CHROMOSOMAL BASIS OF HUMAN INFERTILITY [J].