FUNCTION OF THE HYPOTHALAMO-HYPOPHYSIAL-THYROID AXIS IN CHRONIC RENAL-FAILURE

被引：26
作者：
GOMEZPAN, A
ALVAREZUDE, F
YEO, PPB
HALL, R
EVERED, DC
KERR, DNS
机构：
[1] CIBA FDN,41 PORTLAND PL,LONDON W1N 4BN,ENGLAND
[2] CIUDAD SANIT PRIMERO OCTUBRE,SERV NEFROL,MADRID,SPAIN
[3] FAC MED MADRID,ESCUELA IBEROAMER ENDOCRINOL SEGURIDAD SOCIAL,MADRID 3,SPAIN
[4] UNIV SINGAPORE,DEPT MED,SINGAPORE,SINGAPORE
来源：
CLINICAL ENDOCRINOLOGY | 1979年 / 11卷 / 05期
关键词：
D O I：
10.1111/j.1365-2265.1979.tb03110.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Hypothalamo‐hypophysial‐thyroid function has been studied in twenty‐five patients with chronic renal failure. Eight were receiving conservative treatment, nine peritoneal dialysis and eight haemodialysis. All were clinically euthyroid. Total thyroxine (T4) and triiodothyronine (T3) levels were reduced but free T4 levels were normal, while free T3 was reduced in patients with the most severe renal failure. It is suggested that the binding of thyroid hormones by the transport proteins is reduced and that peripheral conversion of T4 to T3 is impaired in renal failure. The thyrotrophin response to thyrotrophin‐releasing hormone (TRH) is reduced in renal failure but this reduction is probably independent of alterations in thyroid hormone metabolism. Growth hormone was released by TRH in seven of the patients studied, possibly as a result of protein malnutrition. Copyright © 1979, Wiley Blackwell. All rights reserved
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页码：567 / 574
页数：8
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