Recurrent Pregnancy Loss in a Subject with Heterozygote Factor V Leiden Mutation; a Case Report

被引：0

作者：

Ebrahimzadeh-Vesal, Reza ^{[1
]}

Azam, Roza ^{[1
]}

Ghazarian, Arvin ^{[1
]}

Hajesmaeili, Mogge ^{[2
]}

Ranji, Najmeh ^{[3
]}

Ezzati, Mohammad Reza ^{[4
]}

Sadri, Mehrdad ^{[4
]}

Mohammadi, Mohammad Ali ^{[4
]}

Khavandi, Siamak ^{[4
]}

机构：

[1] Univ Tehran Med Sci, Fac Med, Dept Med Genet, Tehran, Iran

[2] Islamic Azad Univ Parand, Dept Biol, Tehran, Iran

[3] Islamic Azad Univ, Rasht Branch, Fac Sci, Dept Genet, Rasht, Iran

[4] Univ Tehran Med Sci, Fac Med, Tehran, Iran

来源：

REPORTS OF BIOCHEMISTRY AND MOLECULAR BIOLOGY | 2014年 / 2卷 / 02期

关键词：

Hereditary thrombophilia; Factor V Leiden mutation; Recurrent pregnancy loss;

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recurrent pregnancy loss is usually defined as the loss of two or more consecutive pregnancies before 20 weeks of gestation, which occurs in approximately 5% of reproductive-aged women. It has been suggested that women with thrombophilia have an increased risk of pregnancy loss and other adverse pregnancy outcomes. Thrombophilia is an important predisposition to blood clot formation and is considered as a significant risk factor for recurrent pregnancy loss. The inherited predisposition to thrombophilia is most often associated with factor V Leiden mutation, prothrombin G20210A mutation, and methylenetetrahydrofolate reductase C677T and A1298C gene variants. The net effect is an increased cleavage of prothrombin to thrombin and excessive blood coagulation.

引用

页码：98 / 102

页数：5

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