THE STRUCTURE OF THE HOMEODOMAIN AND ITS FUNCTIONAL IMPLICATIONS

被引：232

作者：

GEHRING, WJ ^{[1
]}

MULLER, M ^{[1
]}

AFFOLTER, M ^{[1
]}

PERCIVALSMITH, A ^{[1
]}

BILLETER, M ^{[1
]}

QIAN, YQ ^{[1
]}

OTTING, G ^{[1
]}

WUTHRICH, K ^{[1
]}

机构：

[1] SWISS FED INST TECHNOL,INST MOLEK BIOL & BIOPHYS,CH-8093 ZURICH,SWITZERLAND

来源：

TRENDS IN GENETICS | 1990年 / 6卷 / 10期

关键词：

D O I：

10.1016/0168-9525(90)90253-3

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The three-dimensional structure of the homeodomain, as determined by nuclear magnetic resonance spectroscopy, reveals the presence of a helix-turn-helix motif, similar to the one found in prokaryotic gene regulatory proteins. Isolated homeodomains bind with high affinity to specific DNA sequences. Thus, the structure-function relationship is highly conserved in evolution. © 1990.

引用

页码：323 / 329

页数：7

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