Histone Modifications: Epigenetic Mediators of Environmental Exposure Memory

被引：6

作者：

Camacho, Jessica ^{[1
]}

Allard, Patrick ^{[1
,2
]}

机构：

[1] Univ Calif Los Angeles, Mol Toxicol Interdept Program, Los Angeles, CA USA

[2] Univ Calif Los Angeles, Inst Soc & Genet, 3360 Life Sci Bldg, Los Angeles, CA 90095 USA

来源：

EPIGENETICS INSIGHTS | 2018年 / 11卷

关键词：

C; elegans; transgenerational inheritance; reproductive function; Bisphenol A; histone demethylase;

D O I：

10.1177/2516865718803641

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

How organisms retain a memory of ancestral environmental exposure is a phenomenon that is still poorly understood. Recently published work by our group and others, regarding environmentally induced transgenerational effects, have identified an array of mechanisms, with a particular focus on histone modifications, that shed some light on the underlying epigenetic processes driving long-term generational effects.

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