SYNTHESIS AND APPLICATION OF SOME NEW HETEROCYCLO-5-SULFONYL-8-HYDROXYQUINOLINES AS ANTIMICROBIAL AGENTS

被引：0

作者：

HAFEZ, AAA ^{[1
]}

AWAD, IMA ^{[1
]}

ELZOHRY, MF ^{[1
]}

机构：

[1] UNIV ASSIUT,FAC SCI,DEPT CHEM,ASSIUT,EGYPT

来源：

JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY | 1992年 / 54卷 / 04期

关键词：

NICOTINONITRILE; PYRIDONE; CYCLOHEXENONE SULFONYL 8-QUINOLINOL; METAL CHELATE; BIOLOGICAL ACTIVITY;

D O I：

暂无

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A new series of 5-sulphonyl-(-nicotinonitriles, pyridones and cyclohexenones)-8-hydroxyquinolines 2, 3 and 4 have been synthesised by Michael condensation of 5-sulphonyl-(4'-arylidino-3-methyl-2-pyrazoline-5-one)-8-hydroxyquinoline 1 with malononitrile, ethylcyanoacetate and ethylacetoacetate respectively, The metal chelates for compounds 2 and 3 with Cu2+ Hg2+ and Fe3+ have been synthesised. All the prepared compounds were screened in vitro with some selected Gram-positive and Gram-negative bacteria.

引用

页码：369 / 374

页数：6

共 20 条

[1]

ABDELHADI AZ, 1986, POL J PHARM PHARM, V38, P99

[2] TRANSITION-METAL COMPLEXES OF AZO-8-HYDROXYQUINOLINE DERIVATIVES AS ANTIMICROBIAL AGENTS [J].