GALACTOSYL CERAMIDE OR A DERIVATIVE IS AN ESSENTIAL COMPONENT OF THE NEURAL RECEPTOR FOR HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 ENVELOPE GLYCOPROTEIN GP120

被引：219
作者：
BHAT, S
SPITALNIK, SL
GONZALEZSCARANO, F
SILBERBERG, DH
机构：
[1] UNIV PENN,MED CTR,DEPT MICROBIOL & NEUROL,PHILADELPHIA,PA 19104
[2] UNIV PENN,MED CTR,DEPT PATHOL & LAB MED,PHILADELPHIA,PA 19104
来源：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1991年 / 88卷 / 16期
关键词：
AIDS; DEMYELINATION; SULFATIDE; GLYCOLIPID;
D O I：
10.1073/pnas.88.16.7131
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
This report demonstrates that galactosyl ceramide (GalCer) or a molecule derived from it may serve as an alternative receptor for human immunodeficiency virus in the nervous system. Recombinant gp120, an envelope glycoprotein of human immunodeficiency virus type 1, specifically binds to GalCer and its derivatives. This specificity was studied by inhibiting binding of radioiodinated gp120 to GalCer with antibodies to GalCer, antibodies to gp120, and an excess of unlabeled gp120. Binding activity was also removed by absorbing gp120 with liposomes containing GalCer. In addition, studies using natural and semisynthetic lipids indicate that the linkage between galactose and ceramide is essential for binding. The significance of an alternative receptor for human immunodeficiency virus in the nervous system is discussed.
引用
收藏
页码：7131 / 7134
页数：4
相关论文
共 36 条
[1]   MULTIPLE SCLEROSIS-LIKE ILLNESS OCCURRING WITH HUMAN IMMUNODEFICIENCY VIRUS-INFECTION [J].
BERGER, JR ;
SHEREMATA, WA ;
RESNICK, L ;
ATHERTON, S ;
FLETCHER, MA ;
NORENBERG, M .
NEUROLOGY, 1989, 39 (03) :324-329
[2]  
BHAT S, 1986, J NEUROSCI, V6, P3348
[3]  
BHAT S, 1991, T AM SOC NEUROCHEM, V22, P199
[4]   INFECTION OF BRAIN-DERIVED CELLS WITH THE HUMAN-IMMUNODEFICIENCY-VIRUS [J].
CHIODI, F ;
FUERSTENBERG, S ;
GIDLUND, M ;
ASJO, B ;
FENYO, EM .
JOURNAL OF VIROLOGY, 1987, 61 (04) :1244-1247
[5]   SOLUBLE CD4 BLOCKS THE INFECTIVITY OF DIVERSE STRAINS OF HIV AND SIV FOR T-CELLS AND MONOCYTES BUT NOT FOR BRAIN AND MUSCLE-CELLS [J].
CLAPHAM, PR ;
WEBER, JN ;
WHITBY, D ;
MCINTOSH, K ;
DALGLEISH, AG ;
MADDON, PJ ;
DEEN, KC ;
SWEET, RW ;
WEISS, RA .
NATURE, 1989, 337 (6205) :368-370
[6]   MACROPHAGE-TROPIC STRAINS OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 UTILIZE THE CD4 RECEPTOR [J].
COLLMAN, R ;
GODFREY, B ;
CUTILLI, J ;
RHODES, A ;
HASSAN, NF ;
SWEET, R ;
DOUGLAS, SD ;
FRIEDMAN, H ;
NATHANSON, N ;
GONZALEZSCARANO, F .
JOURNAL OF VIROLOGY, 1990, 64 (09) :4468-4476
[7]   THE CD4 (T4) ANTIGEN IS AN ESSENTIAL COMPONENT OF THE RECEPTOR FOR THE AIDS RETROVIRUS [J].
DALGLEISH, AG ;
BEVERLEY, PCL ;
CLAPHAM, PR ;
CRAWFORD, DH ;
GREAVES, MF ;
WEISS, RA .
NATURE, 1984, 312 (5996) :763-767
[8]   SUBACUTE ENCEPHALOMYELITIS OF AIDS AND ITS RELATION TO HTLV-III INFECTION [J].
DELAMONTE, SM ;
HO, DD ;
SCHOOLEY, RT ;
RICHARDSON, EP ;
HIRSCH, MS .
NEUROLOGY, 1987, 37 (04) :562-569
[9]   PERSISTENT PRODUCTIVE INFECTION OF HUMAN GLIAL-CELLS BY HUMAN-IMMUNODEFICIENCY-VIRUS (HIV) AND BY INFECTIOUS MOLECULAR CLONES OF HIV [J].
DEWHURST, S ;
SAKAI, K ;
BRESSER, J ;
STEVENSON, M ;
EVINGERHODGES, MJ ;
VOLSKY, DJ .
JOURNAL OF VIROLOGY, 1987, 61 (12) :3774-3782
[10]   CEREBROSIDE ANTIBODY TITERS IN ANTISERA CAPABLE OF MYELINATION INHIBITION AND DEMYELINATION [J].
DORFMAN, SH ;
FRY, JM ;
SILBERBERG, DH ;
GROSE, C ;
MANNING, MC .
BRAIN RESEARCH, 1978, 147 (02) :410-415
1234