4 FURTHER ANTIBIOTICS RELATED TO OLIVANIC ACID PRODUCED BY STREPTOMYCES-OLIVACEUS - FERMENTATION, ISOLATION, CHARACTERIZATION AND BIOSYNTHETIC-STUDIES

被引：55
作者：
BOX, SJ
HOOD, JD
SPEAR, SR
机构：
[1] Beecham Pharmaceuticals Research Division, Betchworth, Surrey, Brockham Park
来源：
JOURNAL OF ANTIBIOTICS | 1979年 / 32卷 / 12期
关键词：
D O I：
10.7164/antibiotics.32.1239
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Four β-lactam antibiotics with β-lactamase inhibitory activity MM 22380, MM 22381, MM 22382 and MM 22383 containing the carbapenem nucleus have been isolated from a culture of Streptomyces olivaceus ATCC 31365. Fermentation conditions for their production and methods for their isolation are described. Evidence for a biosynthetic link between these compounds and the previously described olivanic acid derivatives MM 4550, MM 13902 and MM 17880 is presented. © 1979, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.
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页码：1239 / 1247
页数：9
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