CORRELATION OF MUTAGENICITY AND 4-(PARA-NITROBENZYL)-PYRIDINE ALKYLATION BY EPOXIDES

被引：78
作者：
HEMMINKI, K
FALCK, K
机构：
来源：
TOXICOLOGY LETTERS | 1979年 / 4卷 / 02期
关键词：
D O I：
10.1016/0378-4274(79)90082-1
中图分类号：
R99 [毒物学（毒理学）];
学科分类号：
100405 ;
摘要：
The reactivity of simple epoxides with 4-(p-nitrobenzyl)-pyridine was compared with their mutagenicity in Salmonella typhimurium TA 100 and Escherichia coli WP 2 uvrA. The order of reactivity correlated well with mutagenicity, trichloropropylene oxide being most potent followed by epichlorohydrin, styrene oxide, glycidol and propylene oxide. The results suggest that 4-(p-nitrobenzyl)-pyridine alkylation is a simple and reliable primary assay in the evaluation of mutagenic properties. © 1979.
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页码：103 / 106
页数：4
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