ASSOCIATION BETWEEN POLYMORPHIC BLOOD MARKERS AND RISK-FACTORS FOR CARDIOVASCULAR-DISEASE IN A LARGE PEDIGREE

被引：19
作者：
GEORGE, VT
ELSTON, RC
AMOS, CI
WARD, LJ
BERENSON, GS
机构：
[1] LOUISIANA STATE UNIV, MED CTR, DEPT BIOMETRY & GENET, 1901 PERDIDO ST, NEW ORLEANS, LA 70112 USA
[2] LOUISIANA STATE UNIV, MED CTR, DEPT MED, NEW ORLEANS, LA 70112 USA
来源：
GENETIC EPIDEMIOLOGY | 1987年 / 4卷 / 04期
关键词：
D O I：
10.1002/gepi.1370040405
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
A large pedigree with high prevalence of heart disease is investigated to analyse the association between polymorphic blood markers and quantitative risk factors for cardiovascular disease. The analysis incorporates a familial correlation structure among the individuals in the pedigree and a generalized power transformation to induce approximate residual normality of the risk factors. A total of 380 marker/risk factor combinations are analysed, and at the nominal 1% significance level, positive associations are found between the A antigen of the ABO locus and both serum total cholesterol and low-density lipoprotein cholesterol, and negative associations are found between the B antigen of the ABO locus and serum total cholesterol, and between the B allele of acid phosphatase (AP) locus and systolic blood pressure.
引用
收藏
页码：267 / 275
页数：9
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