EFFECT OF VERAPAMIL AND ILOPROST (ZK-36374) ON ENDOTHELIN RELEASE AFTER MESENTERIC ISCHEMIA-REPERFUSION INJURY

被引：22

作者：

YEGEN, C ^{[1
]}

AKTAN, AO ^{[1
]}

BUYUKGEBIZ, O ^{[1
]}

HAKLAR, G ^{[1
]}

YALCIN, AS ^{[1
]}

YALIN, R ^{[1
]}

ERCAN, S ^{[1
]}

机构：

[1] MARMARA UNIV HASTANESIL, SCH MED,GENEL CERRAHI BOLUMU, 81190 ISTANBUL, TURKEY

来源：

EUROPEAN SURGICAL RESEARCH | 1994年 / 26卷 / 02期

关键词：

ISCHEMIA REPERFUSION INJURY; ENDOTHELIN; VERAPAMIL; ILOPROST;

D O I：

10.1159/000129320

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

In this experimental study we studied the effect of verapamil and iloprost on endothelin release in ischemia/reperfusion (IR) injury of the rat intestine. Endothelin levels in the portal blood and malondialdehyde (MDA), PGE2, and LTC4 levels in the intestinal tissue were determined. The MDA levels increased in the control group and this increase was reversed with iloprost, verapamil and both. The change in the LTC4 levels was insignificant between the groups. Iloprost reduced PGE2 and endothelin release, but verapamil was not as effective and no synergistic effect was encountered. The increased PGE2/LTC4 ratio was also reversed in the experimental groups, verapamil being less effective. Endothelin release seems to be related to both PGE2 levels and the PGE2/LTC4 ratio after mesenteric IR injury.

引用

页码：69 / 75

页数：7

共 50 条

[31] DIABETES PREDISPOSES THE RAT MESENTERIC MICROVASCULATURE TO ISCHEMIA-REPERFUSION INJURY
PANES, J
KUROSE, I
RODRIGUEZVACA, MD
TSO, P
GRANGER, DN
GASTROENTEROLOGY, 1994, 106 (04) : A260 - A260
[32] Hypocapnia attenuates mesenteric ischemia-reperfusion injury in a rat model
Duggan, M
Engelberts, D
Jankov, RP
Worrall, JMA
Qu, R
Hare, GMT
Tanswell, AK
Mullen, JB
Kavanagh, BP
CANADIAN JOURNAL OF ANAESTHESIA-JOURNAL CANADIEN D ANESTHESIE, 2005, 52 (03): : 262 - 268
[33] Pyrrolidine dithiocarbamate reduces lung injury in mesenteric ischemia-reperfusion
Kabay, B.
Teke, Z.
Ozden, A.
Yenisey, C.
Bir, F.
Bicakci, T.
Erdem, E.
FEBS JOURNAL, 2006, 273 : 155 - 155
[34] Postconditioning: "Toll-erating" mesenteric ischemia-reperfusion injury?
Rosero, Oliver
Onody, Peter
Kovacs, Tibor
Molnar, David
Fulop, Andras
Lotz, Gabor
Harsanyi, Laszlo
Szijarto, Attila
SURGERY, 2017, 161 (04) : 1004 - 1015
[35] Protective effects of hyperbaric oxygen and iloprost on ischemia-reperfusion injury in rabbit kidneys
Ilhan, G.
Aksun, M.
Bozok, S.
Ozpak, H. B.
Gunes, T.
Durakoglugil, M. E.
Kara, H.
Kupeli, A.
Sener, E.
ITALIAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY, 2013, 20 (02): : 89 - 95
[36] Iloprost and pentoxifylline attenuate ischemia-reperfusion injury in skeletal muscle in rabbit model
Emrecan, Bilgin
Tulukoglu, Engin
Bozok, Sahin
Aksun, Murat
Yagdi, Serhan
Ozcan, Ali Vefa
Sacar, Mustafa
Gurbuz, Ali
ULUSAL TRAVMA VE ACIL CERRAHI DERGISI-TURKISH JOURNAL OF TRAUMA & EMERGENCY SURGERY, 2008, 14 (03): : 182 - 187
[37] Protection against liver ischemia-reperfusion injury in rats by silymarin or verapamil
Oliveira, CPMS
Lopasso, FP
Laurindo, FRM
Leitao, RMC
Laudanna, AA
TRANSPLANTATION PROCEEDINGS, 2001, 33 (06) : 3010 - 3014
[38] Visualization of Neutrophil Extracellular Traps in Mesenteric Venules After Mesenteric Ischemia-Reperfusion Injury via Intravital Microscopy
Gao, Zhenling
Dremova, Olga
Karwot, Cornelia
Reinhardt, Christoph
Kiouptsi, Klytaimnistra
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, 2024, (211):
[39] Protective effect of silymarin and verapamil against liver ischemia-reperfusion injury: Possible effect antioxidant.
Oliveira, CPMS
Laurindo, FRM
Lopasso, FP
Leitao, RMC
Sesso, A
Laudanna, AA
HEPATOLOGY, 1998, 28 (04) : 631A - 631A
[40] MORPHOLOGY OF PEROXISOMES AFTER ISCHEMIA-REPERFUSION INJURY
SINGH, AK
GULATI, S
CELLULAR, BIOCHEMICAL, AND MOLECULAR ASPECTS OF REPERFUSION INJURY, 1994, 723 : 403 - 405

← 1 2 3 4 5 →