A REGION-SPECIFIC MICRODISSECTION LIBRARY FOR HUMAN-CHROMOSOME 2P23-]P21 AND THE ANALYSIS OF AN INTERSTITIAL DELETION OF 2P21

被引：9

作者：

KAO, FT

YU, J

QI, J

TONG, S

MUENKE, M

机构：

[1] UNIV COLORADO,HLTH SCI CTR,DEPT BIOCHEM BIOPHYS & GENET,DENVER,CO 80262

[2] CHILDRENS HOSP PHILADELPHIA,PHILADELPHIA,PA 19104

[3] UNIV PENN,SCH MED,DEPT PEDIAT,DIV HUMAN GENET & MOLEC BIOL,PHILADELPHIA,PA 19104

[4] UNIV PENN,SCH MED,DEPT GENET,PHILADELPHIA,PA 19104

来源：

CYTOGENETICS AND CELL GENETICS | 1995年 / 68卷 / 1-2期

关键词：

D O I：

10.1159/000133880

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

A region-specific library of human chromosome 2p23 --> p21 was constructed using microdissection and microcloning techniques. Analysis of 94 single-copy microclones from the library showed that 64% were derived from the dissected region. Ten microclones were further mapped to the 2p21 region using a patient with an interstitial deletion of 2p21 and displaying holoprosencephaly, an abnormal embryonic development in midbrain and midface.

引用

页码：17 / 18

页数：2

共 10 条

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