SYNTHESIS OF RING-C AROMATIC STEROIDS

被引：9

作者：

DALZELL, HC ^{[1
]}

MANMADE, A ^{[1
]}

MASTROCOLA, AR ^{[1
]}

RAZDAN, RK ^{[1
]}

机构：

[1] SISA INC, CAMBRIDGE, MA 02138 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1979年 / 44卷 / 14期

关键词：

D O I：

10.1021/jo01328a026

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A practical multistep synthetic route to ring-C aromatic testosterone analogue 8b from 1, 7-dihydroxynaphthalene (1a) is described. The key intermediate in this sequence is the diketone 7. The synthesis of 8b from 7 was achieved by reduction with sodium borohydride under carefully controlled conditions followed by separation using high-pressure liquid chromatography. Studies with europium shift reagent were used for assigning the β stereochemistry for the 17-hydroxy group of 8b. © 1979, American Chemical Society. All rights reserved.

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页码：2457 / 2461

页数：5

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