ANTIBIOTIC DE-ESCALATION IN THE INTENSIVE THERAPY UNIT- A REVIEW

被引：0

作者：

Sharma, Jyoti ^{[1
]}

Kosey, Sourabh ^{[1
]}

Kumar, Raj ^{[2
]}

机构：

[1] ISF Coll Pharm, Dept Pharm Practice, Moga 142001, Punjab, India

[2] Guru Gobind Singh Med Coll & Hosp, Dept Pharmacol, Faridkot 151203, Punjab, India

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH | 2016年 / 7卷 / 09期

关键词：

ITU - (Intensive Therapy Unit); MDR - (Multi Drug Resistant); Antibiotics; MRSA ("methicillin-resistant Staphylococcus aureus) PCT: (Procalcitonin);

D O I：

10.13040/IJPSR.0975-8232.7(9).3596-01

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

An antibiotic may be defined as a substance or compound that kills or inhibits the growth of, bacteria. Antibiotics belong to the broader group of antimicrobial compounds, used to treat infections caused by microorganisms, including fungi and protozoa, viruses. Antibiotic de-escalation is a mechanism whereby the provision of effective initial antibiotic treatment is achieved while avoiding unnecessary antibiotic use that would promote the development of resistance. The embodiment of de-escalation is that based on microbiology results around the day 3 therapy point; the empiric antibiotic(s) that were started are stopped or reduced in number and/or narrowed in spectrum.

引用

页码：3596 / 3601

页数：6

共 26 条

[1] Timing of Antimicrobial Therapy after Identification of Ventilator-Associated Condition Is Not Associated with Mortality in Patients with Ventilator-Associated Pneumonia: A Cohort Study
Amaral, Andre C. K. B.
Holder, Michael W.
[J]. PLOS ONE, 2014, 9 (05):
[2] Guidelines for the management, of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia
不详
[J]. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2005, 171 (04) : 388 - 416
[3] Antibiotic Stewardship in the Intensive Care Unit
Arnold, Heather M.
Micek, Scott T.
Skrupky, Lee P.
Kollef, Marin H.
[J]. SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE, 2011, 32 (02) : 215 - 227
[4] Indications for antibiotic use in ICU patients: a one-year prospective surveillance
Bergmans, DCJJ
Bonten, MJM
Gaillard, CA
vanTiel, FH
vanderGeest, S
deLeeuw, PW
Stobberingh, EE
[J]. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1997, 39 (04) : 527 - 535
[5] DELLINGER RP, 2013, INTENS CARE MED, V39, P165, DOI DOI 10.1007/s00134-012-2769-8
[6] Strategies to prevent and control the emergence and spread of antimicrobial-resistant microorganisms in hospitals - A challenge to hospital leadership
Goldmann, DA
Weinstein, RA
Wenzel, RP
Tablan, OC
Duma, RJ
Gaynes, RP
Schlosser, J
Martone, WJ
[J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1996, 275 (03): : 234 - 240
[7] Inadequate antimicrobial treatment: An important determinant of outcome for hospitalized patients
Kollef, MH
[J]. CLINICAL INFECTIOUS DISEASES, 2000, 31 : S131 - S138
[8] Optimizing antibiotic therapy in the intensive care unit setting
Kollef M.H.
[J]. Critical Care, 5 (4): : 189 - 195
[9] Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock
Kumar, Arland
Roberts, Daniel
Wood, Kenneth E.
Light, Bruce
Parrillo, Joseph E.
Sharma, Satendra
Suppes, Robert
Feinstein, Daniel
Zanotti, Sergio
Taiberg, Leo
Gurka, David
Kumar, Aseem
Cheang, Mary
[J]. CRITICAL CARE MEDICINE, 2006, 34 (06) : 1589 - 1596
[10] Antibiotic resistance-the need for global solutions
Laxminarayan, Ramanan
Duse, Adriano
Wattal, Chand
Zaidi, Anita K. M.
Wertheim, Heiman F. L.
Sumpradit, Nithima
Vlieghe, Erika
Levy Hara, Gabriel
Gould, Ian M.
Goossens, Herman
Greko, Christina
So, Anthony D.
Bigdeli, Maryam
Tomson, Goeran
Woodhouse, Will
Ombaka, Eva
Peralta, Arturo Quizhpe
Qamar, Farah Naz
Mir, Fatima
Kariuki, Sam
Bhutta, Zulfigar A.
Coates, Anthony
Bergstrom, Richard
Wright, Gerard D.
Brown, Eric D.
Cars, Otto
[J]. LANCET INFECTIOUS DISEASES, 2013, 13 (12) : 1057 - 1098

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