ISOLATION OF A CDNA-ENCODING A HUMAN ROLIPRAM-SENSITIVE CYCLIC-AMP PHOSPHODIESTERASE (PDE IVD)

被引：42
作者：
BAECKER, PA
OBERNOLTE, R
BACH, C
YEE, C
SHELTON, ER
机构：
[1] Syntex Discovery Research, Institute of Bio-Organic Chemistry, Palo Alto
来源：
GENE | 1994年 / 138卷 / 1-2期
关键词：
HEART LIBRARY; RAT HOMOLOG; SKELETAL TISSUE;
D O I：
10.1016/0378-1119(94)90818-4
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
cDNAs encoding human family-IV phosphodiesterase, subtype D (hPDE IVD) were isolated from a human heart cDNA library. The overlapping cDNAs encode a polypeptide of 604 amino acids (aa) with a predicted M(r) of 68 502, which is 91.4% identical to the rat homolog, rPDE IVD. hPDE IVD produced in Escherichia coli was inhibited by rolipram. Expression of the hPDE IVD mRNA is widespread in human tissues and most abundant in skeletal muscle.
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页码：253 / 256
页数：4
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