MELATONIN AS IMMUNOMODULATOR IN IMMUNODEFICIENT MICE

被引：112

作者：

CAROLEO, MC

FRASCA, D

NISTICO, G

DORIA, G

机构：

[1] CTR RIC ENERGIA CASACCIA, ENTE NAZL ENERGIE ALTERNAT, DIV PHYS & BIOMED SCI, CP 2400, I-00100 ROME, ITALY

[2] UNIV ROME, DEPT BIOL, TOR VERGATA, ITALY

来源：

IMMUNOPHARMACOLOGY | 1992年 / 23卷 / 02期

关键词：

MELATONIN; IMMUNODEFICIENCY; T-CELL; IL-2; ANTIBODY;

D O I：

10.1016/0162-3109(92)90031-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Melatonin, the main hormone of the pineal gland, when chronically injected into young mice or mice immunodepressed by aging or by cyclophosphamide treatment, is able to enhance the antibody response to a T-dependent antigen. The enhancement of the antibody response is associated with increased induction of T helper cell activity and IL-2 production, as evidenced in mice immunodepressed by aging or by cyclophosphamide treatment. These observations suggest that melatonin treatment may be successfully used in the therapy of immunodepressive conditions.

引用

页码：81 / 89

页数：9

共 26 条

[11] AGE-DEPENDENT REDUCTION IN SERUM MELATONIN CONCENTRATIONS IN HEALTHY-HUMAN SUBJECTS [J].