EXCESSIVE CHOLESTEROLEMIC RESPONSE IN ANALBUMINEMIC RATS FED A CHOLESTEROL-RICH DIET CONTAINING CASEIN

被引:11
作者
ZHANG, XZ
JOLES, JA
KOOMANS, HA
VANTOL, A
BEYNEN, AC
机构
[1] UNIV UTRECHT,DEPT LAB ANIM SCI,UTRECHT,NETHERLANDS
[2] UNIV UTRECHT HOSP,DEPT NEPHROL & HYPERTENS,3511 GV UTRECHT,NETHERLANDS
[3] AGR UNIV WAGENINGEN,DEPT HUMAN NUTR,6700 HB WAGENINGEN,NETHERLANDS
[4] ERASMUS UNIV,DEPT BIOCHEM 1,3000 DR ROTTERDAM,NETHERLANDS
关键词
ANALBUMINEMIA; DIETARY PROTEIN; DIETARY CHOLESTEROL; PLASMA CHOLESTEROL; RATS;
D O I
10.1093/jn/122.3.520
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Female Nagase analbuminemic rats and Sprague-Dawley rats were fed purified diets with or without 1% cholesterol and containing either soybean protein or casein. After consuming the cholesterol-free diets, the analbuminemic rats had significantly higher plasma cholesterol and triglyceride concentrations than the Sprague-Dawley rats. The higher plasma cholesterol levels were essentially in the low density and high density lipoproteins. Based on the fact that the analbuminemic rats excreted more bile acids in feces it is possible that the higher baseline plasma cholesterol concentrations in Nagase analbuminemic rats were partly caused by overproduction of cholesterol. The Nagase analbuminemic rats displayed a greater cholesterolemic response to cholesterol feeding than Sprague-Dawley rats, but only if casein was the protein source in the diet. Casein vs. soybean protein in either cholesterol-free or high cholesterol diets reduced bile acid excretion in Sprague-Dawley but not in Nagase analbuminemic rats. The increased sensitivity to casein plus cholesterol feeding in Nagase analbuminemic rats may be caused by a lack of inhibition of de novo cholesterol synthesis.
引用
收藏
页码:520 / 527
页数:8
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