INTERACTION BETWEEN PROFLAVIN AND DEOXYTETRARIBONUCLEOSIDE TRIPHOSPHATE 5'-D(APGPCPT) - THERMODYNAMIC ANALYSIS ACCORDING TO H-1-NMR DATA

被引：0
|
作者：
VESELKOV, AN [1 ]
DEVIS, D [1 ]
DYMANT, LN [1 ]
PARKES, H [1 ]
SHIPP, D [1 ]
机构：
[1] UNIV LONDON BIRKBECK COLL,LONDON WC1E 7HX,ENGLAND
来源：
BIOFIZIKA | 1992年 / 37卷 / 05期
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D O I：
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中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
Temperature relationships of chemical shifts of protons of proflavin mixed with deoxytetraribonucleoside triphosphate 5'-d(ApGpCpT) in water solution were investigated on impulse NMR spectrometer (500 MHz). Procedure is suggested for calculating values of mole fractions of various associates in solution as a function against temperature. Free energies of Gibbs, entalpy and entropy were determined in the reactions of complex formation 1 : 1, 1 : 2, 2 : 1 of proflavin with tetranucleotide. The results point to a significant role of hydrophobic interactions during the formation of dye - tetramere duplex complexes.
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页码：851 / 858
页数：8
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