Successful treatment of C. auris shunt infection with intraventricular caspofungin

被引：19

作者：

Singhal, Tanu ^{[1
]}

Kumar, Abhaya ^{[1
]}

Borade, Prashant ^{[1
]}

Shah, Sweta ^{[1
]}

Soman, Rajeev ^{[2
,3
,4
,5
]}

机构：

[1] Kokilaben Dhirubhai Ambani Hosp & Med Res Inst, Bombay 400053, Maharashtra, India

[2] Jupiter Hosp, Pune, Maharashtra, India

[3] DMH, Pune, Maharashtra, India

[4] Bharti Vidyapeeth Hosp, Pune, Maharashtra, India

[5] Hinduja Hosp, Bombay, Maharashtra, India

来源：

MEDICAL MYCOLOGY CASE REPORTS | 2018年 / 22卷

基金：

英国医学研究理事会;

关键词：

C; auris; CSF shunt; Intraventricular caspofungin;

D O I：

10.1016/j.mmcr.2018.08.005

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

C. auris is an emerging fungal pathogen with high prevalence of resistance to current antifungal agents. Central nervous system infection with C. auris has been infrequently described. We describe here an adult with nosocomial CSF shunt infection due to multi drug resistant C. auris. Systemic therapy with echinocandin and flucytosine failed. Fortunately, administration of daily intraventricular caspofungin 10 mg for 10 days in conjunction with systemic voriconazole resulted in both clinical and microbiological cure.

引用

页码：35 / 37

页数：3

共 19 条

[1]

[Anonymous], 2017, CAND AUR INT REC HEA

[2]

Arendrup MC, 2017, ANTIMICROB AGENTS CH, V61

[3] Pharmacology of systemic antifungal agents [J].

Ashley, Elizabeth S. Dodds ;

Lewis, Russell ;

Lewis, James S. ;

Martin, Craig ;

Andes, David .

CLINICAL INFECTIOUS DISEASES, 2006, 43 :S28-S39

[4] Controlling a possible outbreak of Candida auris infection: lessons learnt from multiple interventions [J].

Biswal, M. ;

Rudramurthy, S. M. ;

Jain, N. ;

Shamanth, A. S. ;

Sharma, D. ;

Jain, K. ;

Yaddanapudi, L. N. ;

Chakrabarti, A. .

JOURNAL OF HOSPITAL INFECTION, 2017, 97 (04) :363-370

[5] Incidence, characteristics and outcome of ICU-acquired candidemia in India [J].

Chakrabarti, Arunaloke ;

Sood, Prashant ;

Rudramurthy, Shivaprakash M. ;

Chen, Sharon ;

Kaur, Harsimran ;

Capoor, Malini ;

Chhina, Deepinder ;

Rao, Ratna ;

Eshwara, Vandana Kalwaje ;

Xess, Immaculata ;

Kindo, Anupama J. ;

Umabala, P. ;

Savio, Jayanthi ;

Patel, Atul ;

Ray, Ujjwayini ;

Mohan, Sangeetha ;

Iyer, Ranganathan ;

Chander, Jagdish ;

Arora, Anita ;

Sardana, Raman ;

Roy, Indranil ;

Appalaraju, B. ;

Sharma, Ajanta ;

Shetty, Anjali ;

Khanna, Neelam ;

Marak, Rungmei ;

Biswas, Sanjay ;

Das, Shukla ;

Harish, B. N. ;

Joshi, Sangeeta ;

Mendiratta, Deepak .

INTENSIVE CARE MEDICINE, 2015, 41 (02) :285-295

[6] Candida auris: A rapidly emerging cause of hospital-acquired multidrug-resistant fungal infections globally [J].

Chowdhary, Anuradha ;

Sharma, Cheshta ;

Meis, Jacques F. .

PLOS PATHOGENS, 2017, 13 (05)

[7]

European Centre for Disease Prevention and Control, 2016, CAND AUR HEALTHC SET

[8]

Fakhim H., 2017, ANTIMICROB AGENTS CH, V61

[9]

Indian Council of Medical Research, 2018, CAND AUR HEALTHC SET

[10] Multidrug-Resistant Candida auris Misidentified as Candida haemulonii: Characterization by Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry and DNA Sequencing and Its Antifungal Susceptibility Profile Variability by Vitek 2, CLSI Broth Microdilution, and Etest Method [J].

Kathuria, Shallu ;

Singh, Pradeep K. ;

Sharma, Cheshta ;

Prakash, Anupam ;

Masih, Aradhana ;

Kumar, Anil ;

Meis, Jacques F. ;

Chowdhary, Anuradha .

JOURNAL OF CLINICAL MICROBIOLOGY, 2015, 53 (06) :1823-1830

← 1 2 →