THE USE OF A RADIOLABELED SACCHARIN SOLUTION TO MONITOR THE EFFECT OF THE PRESERVATIVES THIOMERSAL, BENZALKONIUM CHLORIDE AND EDTA ON HUMAN NASAL CLEARANCE

被引：21

作者：

BATTS, AH

MARRIOTT, C

MARTIN, GP

BOND, SW

GREAVES, JL

WILSON, CG

机构：

[1] BRIGHTON POLYTECH,DEPT PHARM,PHARMACEUT SCI RES GRP,BRIGHTON BN2 4GJ,E SUSSEX,ENGLAND

[2] WELLCOME FDN LTD,DARTFORD,KENT,ENGLAND

[3] QUEENS MED CTR,DEPT PHYSIOL & PHARMACOL,NOTTINGHAM NG7 2UH,ENGLAND

来源：

JOURNAL OF PHARMACY AND PHARMACOLOGY | 1991年 / 43卷 / 03期

关键词：

D O I：

10.1111/j.2042-7158.1991.tb06662.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effect of thiomersal, benzalkonium chloride and ethylenediaminetetraacetic acid (EDTA) on the nasal mucociliary clearance of healthy volunteers has been investigated using a modified saccharin test and gamma scintigraphy concomitantly. A significant correlation was found between the two techniques. Using each subject as his/her own control, none of the preservatives significantly altered the rate of clearance or proportion cleared from the nasal cavity after the administration of a single dose. This result is at variance with some in-vitro findings.

引用

页码：180 / 185

页数：6

共 39 条

[21] ADVERSE-EFFECTS OF LIDOCAINE AND METHYLPARABEN ON TRACHEAL CILIARY ACTIVITY [J].