THE USE OF A RADIOLABELED SACCHARIN SOLUTION TO MONITOR THE EFFECT OF THE PRESERVATIVES THIOMERSAL, BENZALKONIUM CHLORIDE AND EDTA ON HUMAN NASAL CLEARANCE

被引：21
作者：
BATTS, AH
MARRIOTT, C
MARTIN, GP
BOND, SW
GREAVES, JL
WILSON, CG
机构：
[1] BRIGHTON POLYTECH,DEPT PHARM,PHARMACEUT SCI RES GRP,BRIGHTON BN2 4GJ,E SUSSEX,ENGLAND
[2] WELLCOME FDN LTD,DARTFORD,KENT,ENGLAND
[3] QUEENS MED CTR,DEPT PHYSIOL & PHARMACOL,NOTTINGHAM NG7 2UH,ENGLAND
来源：
JOURNAL OF PHARMACY AND PHARMACOLOGY | 1991年 / 43卷 / 03期
关键词：
D O I：
10.1111/j.2042-7158.1991.tb06662.x
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The effect of thiomersal, benzalkonium chloride and ethylenediaminetetraacetic acid (EDTA) on the nasal mucociliary clearance of healthy volunteers has been investigated using a modified saccharin test and gamma scintigraphy concomitantly. A significant correlation was found between the two techniques. Using each subject as his/her own control, none of the preservatives significantly altered the rate of clearance or proportion cleared from the nasal cavity after the administration of a single dose. This result is at variance with some in-vitro findings.
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收藏
页码：180 / 185
页数：6
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