CHROMOSOME-ABNORMALITIES IN BREAST FIBROADENOMAS

被引：46

作者：

CALABRESE, G

DIVIRGILIO, C

CIANCHETTI, E

FRANCHI, PG

STUPPIA, L

PARRUTI, G

BIANCHI, PG

PALKA, G

机构：

[1] UNIV CHIETI,IST BIOL & GENET,CHIETI,ITALY

[2] UNIV CHIETI,IST PATOL CHIRURG,CHIETI,ITALY

[3] CNR,IST CITOMORFOL,CHIETI,ITALY

来源：

GENES CHROMOSOMES & CANCER | 1991年 / 3卷 / 03期

关键词：

D O I：

10.1002/gcc.2870030305

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A cytogenetic study on 25 breast fibroadenomas from 17 women is reported. Seven tumors in five patients showed clonal structural chromosome changes. In three patients the breaks involved chromosome 12, occurring in two tumors in band 12p12 and in band 12q15 in all three tumors of one patient. The finding of an identical aberration, t(11;12)(q21;q15), in three adenomas from the same patient strongly suggests a clonal origin of multiple fibroadenomas of the breast.

引用

页码：202 / 204

页数：3

共 13 条

[1]

FLETCHER J A, 1989, American Journal of Human Genetics, V45, pA21

[2]

Harnden DG, 1985, BIRTH DEFECTS ORIGIN, V21

[3]

HEIM S, 1987, CANCER CYTOGENETICS

[4]

KHISHIN AF, 1976, 1976 INT C HUM GEN, P133