SYNTHESIS AND ANTIBACTERIAL EVALUATION OF 1-(4-THIAZOLYLMETHYL)AMINO-SUBSTITUTED AND 7-(4-THIAZOLYLMETHYL)AMINO-SUBSTITUTED QUINOLONES

被引：2

作者：

ZHANG, MQ

LEVSHIN, I

VANDENBERGHE, D

HAEMERS, A

机构：

[1] UNIV INSTELLING ANTWERP,DEPT PHARMACEUT CHEM,B-2610 WILRIJK,BELGIUM

[2] UNIV INSTELLING ANTWERP,DEPT MICROBIOL,B-2610 WILRIJK,BELGIUM

[3] ALL UNION CHEM & PHARMACEUT INST,MOSCOW,RUSSIA

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 1991年 / 26卷 / 03期

关键词：

THIAZOLYLMETHYL SUBSTITUTED QUINOLONES; ANTIBACTERIAL ACTIVITY;

D O I：

10.1016/0223-5234(91)90066-V

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A group of 6-fluoro-1,4-dihydro-4-oxo-7-piperazinyl-1-(4-thiazolylmethyl)quinoline-3-carboxylic acids and 1-ethyl-6-fluoro-1,4-dihydro-7-(2-methyl-4-thiazolyl) methylamino-4-oxoquinoline-3-carboxylic acid were synthesized. All compounds were tested in vitro against a series of Gram-positive and Gram-negative bacteria. No important antibacterial activity was found among the compounds tested.

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页码：331 / 334

页数：4

相关论文

共 12 条

[1]

Albrecht R, 1977, Prog Drug Res, V21, P9

[2] THE SYNTHESIS OF 4-CHLOROMETHYLTHIAZOLE HYDROCHLORIDE AND BETA-(4-THIAZOLYL)-ALANINE HYDROCHLORIDE [J].

CALDWELL, WT ;

FOX, SM .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1951, 73 (06) :2935-2936

[3] STRUCTURE-ACTIVITY-RELATIONSHIPS OF THE FLUOROQUINOLONES [J].

CHU, DTW ;

FERNANDES, PB .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1989, 33 (02) :131-135

[4] A-61827 (A-60969), A NEW FLUORONAPHTHYRIDINE WITH ACTIVITY AGAINST BOTH AEROBIC AND ANAEROBIC-BACTERIA [J].

FERNANDES, PB ;

CHU, DTW ;

SWANSON, RN ;

RAMER, NR ;

HANSON, CW ;

BOWER, RR ;

STAMM, JM ;

HARDY, DJ .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1988, 32 (01) :27-32

[5] INVITRO AND INVIVO POTENCY OF 5 NEW FLUOROQUINOLONES AGAINST ANAEROBIC-BACTERIA [J].

FERNANDES, PB ;

SHIPKOWITZ, N ;

BOWER, RR ;

JARVIS, KP ;

WEISZ, J ;

CHU, DTW .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1986, 18 (06) :693-701

[6]

FRNANDS PB, 1988, ANNU REP MED CHEM, V23, P133

[7] INVITRO AND INVIVO ANTIBACTERIAL ACTIVITIES OF BMY-40062, A NEW FLUORONAPHTHYRIDONE [J].

FUNGTOMC, J ;

DESIDERIO, JV ;

TSAI, YH ;

WARR, G ;

KESSLER, RE .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1989, 33 (06) :906-914

[8] The polymerization of 2-methyl-4-chloromethylthiazole XII [J].

Hooper, FE ;

Johnson, TB .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1934, 56 :470-471

[9] THE SYNTHESIS OF 1-[(2-THIAZOLYL)METHYL]QUINOLONES - THE REACTIVITY OF THE METHYLENE BRIDGE AT POSITION-1 AND ITS INVOLVEMENT IN THE FORMATION OF A STABLE CARBON-NITROGEN YLID [J].

IZZO, PT ;

LEE, VJ .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 1988, 25 (01) :289-295

[10] STRUCTURE-ACTIVITY-RELATIONSHIPS OF ANTI-BACTERIAL 6,7-DISUBSTITUTED AND 7,8-DISUBSTITUTED 1-ALKYL-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXYLIC ACIDS [J].

KOGA, H ;

ITOH, A ;

MURAYAMA, S ;

SUZUE, S ;

IRIKURA, T .

JOURNAL OF MEDICINAL CHEMISTRY, 1980, 23 (12) :1358-1363