Successful sequential treatment of refractory tumors caused by small cell carcinoma transformation and EGFR-T790M mutation diagnosed by repeated genetic testing in a patient with lung adenocarcinoma harboring epidermal growth factor receptor mutations: A case report

被引：8

作者：

Nishioka, Naoya ^{[1
]}

Yamada, Tadaaki ^{[1
]}

Harita, Sachi ^{[1
]}

Hirai, Soichi ^{[1
]}

Katayama, Yuki ^{[1
]}

Nakano, Takayuki ^{[1
]}

Okura, Naoko ^{[1
]}

Tamiya, Nobuyo ^{[1
]}

Kaneko, Yoshiko ^{[1
]}

Uchino, Junji ^{[1
]}

Takayama, Koichi ^{[1
]}

机构：

[1] Kyoto Prefectural Univ Med, Grad Sch Med Sci, Dept Pulm Med, Kyoto, Japan

来源：

RESPIRATORY MEDICINE CASE REPORTS | 2018年 / 25卷

关键词：

Repeated genetic testing; Drug resistance; EGFR-T790M; SCLC transformation; Liquid biopsy;

D O I：

10.1016/j.rmcr.2018.10.004

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

NSCLC patients with EGFR mutations respond to EGFR-TKIs; however, the management of refractory tumors to EGFR-TKIs remains unclear. We demonstrated that repeated genetic testing might be useful for detecting resistance mechanisms as well as for decision-making in EGFR mutated NSCLC patients, following the emergence of resistance to the initial EGFR-TKIs. A 69-year-old man was diagnosed with lung adenocarcinoma with an EGFR exon 19 deletion. After tumor regrowth treated with erlotinib and chemotherapy, he was diagnosed with an SCLC transformation and administered chemotherapy to treat the SCLC. After the resistance of chemotherapy, the EGFR-T790M mutation by liquid biopsy was detected and treated him with osimertinib, which resulted in a clinical response.

引用

页码：261 / 263

页数：3

共 17 条

[1] Interstitial Lung Disease Associated with Gefitinib in Japanese Patients with EGFR-mutated Non-small-cell Lung Cancer: Combined Analysis of Two Phase III Trials (NEJ 002 and WJTOG 3405) [J].

Akamatsu, Hiroaki ;

Inoue, Akira ;

Mitsudomi, Tetsuya ;

Kobayashi, Kunihiko ;

Nakagawa, Kazuhiko ;

Mori, Keita ;

Nukiwa, Toshihiro ;

Nakanishi, Yoichi ;

Yamamoto, Nobuyuki .

JAPANESE JOURNAL OF CLINICAL ONCOLOGY, 2013, 43 (06) :664-668

[2] Small cell lung cancer transformation and the T790M mutation: A case report of two acquired mechanisms of TKI resistance detected in a tumor rebiopsy and plasma sample of EGFR-mutant lung adenocarcinoma [J].

Ali, Greta ;

Bruno, Rossella ;

Giordano, Mirella ;

Prediletto, Irene ;

Marconi, Letizia ;

Zupo, Simonetta ;

Fedeli, Franco ;

Ribechini, Alessandro ;

Chella, Antonio ;

Fontanini, Gabriella .

ONCOLOGY LETTERS, 2016, 12 (05) :4009-4012

[3]

Araki T., 2017, ANN JPN RESP SOC, V6, P99

[4]

Fujita K, 2017, RESPIROL CASE REP, V5, DOI 10.1002/rcr2.206

[5] Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing [J].

Gerlinger, Marco ;

Rowan, Andrew J. ;

Horswell, Stuart ;

Larkin, James ;

Endesfelder, David ;

Gronroos, Eva ;

Martinez, Pierre ;

Matthews, Nicholas ;

Stewart, Aengus ;

Tarpey, Patrick ;

Varela, Ignacio ;

Phillimore, Benjamin ;

Begum, Sharmin ;

McDonald, Neil Q. ;

Butler, Adam ;

Jones, David ;

Raine, Keiran ;

Latimer, Calli ;

Santos, Claudio R. ;

Nohadani, Mahrokh ;

Eklund, Aron C. ;

Spencer-Dene, Bradley ;

Clark, Graham ;

Pickering, Lisa ;

Stamp, Gordon ;

Gore, Martin ;

Szallasi, Zoltan ;

Downward, Julian ;

Futreal, P. Andrew ;

Swanton, Charles .

NEW ENGLAND JOURNAL OF MEDICINE, 2012, 366 (10) :883-892

[6] Comparison of detection methods of EGFR T790M mutations using plasma, serum, and tumor tissue in EGFR-TKI-resistant non-small cell lung cancer [J].

Kobayashi, Keigo ;

Naoki, Katsuhiko ;

Manabe, Tadashi ;

Masuzawa, Keita ;

Hasegawa, Hanako ;

Yasuda, Hiroyuki ;

Kawada, Ichiro ;

Soejima, Kenzo ;

Betsuyaku, Tomoko .

ONCOTARGETS AND THERAPY, 2018, 11 :3335-3343

[7] Incidence of T790M mutation in (sequential) rebiopsies in EGFR-mutated NSCLC-patients [J].

Kuiper, J. L. ;

Heideman, D. A. M. ;

Thunnissen, E. ;

Paul, M. A. ;

van Wijk, A. W. ;

Postmus, P. E. ;

Smit, E. F. .

LUNG CANCER, 2014, 85 (01) :19-24

[8] Profile of the Roche cobas® EGFR mutation test v2 for non-small cell lung cancer [J].

Malapelle, Umberto ;

Sirera, Rafael ;

Jantus-Lewintre, Eloisa ;

Reclusa, Pablo ;

Calabuig-Farinas, Silvia ;

Blasco, Ana ;

Pisapia, Pasquale ;

Rolfo, Christian ;

Camps, Carlos .

EXPERT REVIEW OF MOLECULAR DIAGNOSTICS, 2017, 17 (03) :209-215

[9] RB loss in resistant EGFR mutant lung adenocarcinomas that transform to small-cell lung cancer [J].

Niederst, Matthew J. ;

Sequist, Lecia V. ;

Poirier, John T. ;

Mermel, Craig H. ;

Lockerman, Elizabeth L. ;

Garcia, Angel R. ;

Katayama, Ryohei ;

Costa, Carlotta ;

Ross, Kenneth N. ;

Moran, Teresa ;

Howe, Emily ;

Fulton, Linnea E. ;

Mulvey, Hillary E. ;

Bernardo, Lindsay A. ;

Mohamoud, Farhiya ;

Miyoshi, Norikatsu ;

VanderLaan, Paul A. ;

Costa, Daniel B. ;

Jaenne, Pasi A. ;

Borger, Darrell R. ;

Ramaswamy, Sridhar ;

Shioda, Toshi ;

Iafrate, Anthony J. ;

Getz, Gad ;

Rudin, Charles M. ;

Mino-Kenudson, Mari ;

Engelman, Jeffrey A. .

NATURE COMMUNICATIONS, 2015, 6

[10] Transformation from non-small-cell lung cancer to small-cell lung cancer: molecular drivers and cells of origin [J].

Oser, Matthew G. ;

Niederst, Matthew J. ;

Sequist, Lecia V. ;

Engelman, Jeffrey A. .

LANCET ONCOLOGY, 2015, 16 (04) :E165-E172

← 1 2 →