EXTENDED RELEASE FELODIPINE IN ESSENTIAL-HYPERTENSION - VARIATIONS IN BLOOD-PRESSURE DURING WHOLE-DAY CONTINUOUS AMBULATORY RECORDING

被引：30
作者：
FARIELLO, R
BONI, E
CORDA, L
CANTALAMESSA, A
ZANINELLI, A
POLLAVINI, G
ALICANDRI, C
MUIESAN, G
机构：
[1] Clinica Medica Generate, Department of Internal Medi­cine, University of Brescia
来源：
AMERICAN JOURNAL OF HYPERTENSION | 1991年 / 4卷 / 01期
关键词：
ESSENTIAL HYPERTENSION; BLOOD PRESSURE MONITORING; FELODIPINE; CALCIUM ENTRY BLOCKADE;
D O I：
10.1093/ajh/4.1.27
中图分类号：
R6 [外科学];
学科分类号：
1002 ; 100210 ;
摘要：
Intraarterial blood pressure (BP) monitoring during free ambulation (Oxford technique) was carried out in 12 essential mild-to-moderate hypertensive patients undergoing 4 weeks treatment with felodipine, 10 mg given once daily in an extended release formulation. Compared to placebo, felodipine significantly reduced systolic and diastolic blood pressure throughout 24 h. The greatest reduction was observed at 10 AM, 3 h after drug administration (-32 +/- 6/-24 +/- 5 mm Hg for systolic and diastolic BP, respectively, P < .001). Hourly BP values remained significantly lower up to and including the 24th hour during felodipine extended release treatment (-18 +/- 5/-11 +/- 3 mm Hg, P < .001). Felodipine extended release also reduced 24 h blood pressure variability, evaluated on the standard deviation of each hourly mean (from 16.3 +/- 0.9/ 12.6 +/- 0.6 to 13.4 +/- 0.6/10.4 +/- 0.6 mm Hg, P < .01). Furthermore, absolute BP values dropped significantly at the peaks of dynamic exercise (bicycle ergometer: from 248 +/- 13/123 +/- 11 to 204 +/- 24/102 +/- 13 mm Hg, P < .001), isometric exercise (hand grip: from 232 +/- 18/133 +/- 16 to 180 +/- 20/101 +/- 16 mm Hg, P < .001), and cold pressor test (from 229 +/- 20/ 127 +/- 14 to 178 +/- 22/99 +/- 15 mm Hg, P < .001). In conclusion, felodipine extended release exerts a good antihypertensive effect which is maintained for 24 h and reduces the level of blood pressure peaks reached under different physical stresses.
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页码：27 / 33
页数：7
相关论文
共 23 条
  • [1] Elmfeldt D., Hedner T., Westerling S., Felodipinè in hypertension—a review, J Cardiovasc Pharmacol, 10, pp. 154s-160s, (1987)
  • [2] Felodipine, a New Calcium Antagonist, as Monotherapy in Mild Or Moderate Hypertension. Drugs, 34, pp. 139-148, (1987)
  • [3] Leonetti G., Gradnik R., Terzoli L., Et al., Felodipine, a new vasodilating drug: Blood pressure, cardiac, renal, and humoral effects in hypertensive patients, J Hypertens, 3, pp. 392-398, (1984)
  • [4] Hedner T., Elmfeldt D., Dahlof C., Sjogren E., Comparison of antihypertensive effect and pharmacokinetics of conventional and extended release felodipine tablets in patients with arterial hypertension, Drugs, 34, pp. 125-131, (1987)
  • [5] Alicandri C., Fariello R., Boni E., Et al., Autonomic nervous system control of heart rate in essential hypertension, J Hypertens, 3, pp. 117s-119s, (1985)
  • [6] Littler W.A., Honour A.J., Sleight P., Stott F.D., Continuous recording of direct arterial pressure and electrocardiogram in unrestricted man, Br Med J, 3, pp. 76-78, (1972)
  • [7] Fariello R., Alicandri C., Boni E., Et al., Continuous haemodynamic ambulatory monitoring in essential hypertension, J Hypertens, 3, pp. 367s-369s, (1985)
  • [8] Pessina A.C., Palatini P., Sperti G., Et al., Evaluation of hypertension and related target organ damage by average day-time blood pressure, Clin Exp Hypertens [A], 7, pp. 267-272, (1985)
  • [9] Di Rienzo M., Grassi G., Pedotti A., Manda G., Continuous vs intermittent blood pressure measurements in estimating 24-hour average blood pressure, Hypertension, 5, pp. 264-269, (1983)
  • [10] Littler W.A., Honour A.J., Pugsley D.J., Sleight P., Continuous recording of direct arterial pressure in unrestricted patients: Its role in the diagnosis and management of high blood pressure, Circulation, 51, pp. 1101-1106, (1975)
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