6-BETA [N,N-BIS(2-CHLOROETHYL)AMINO]-17-(CYCLOPROPYLMETHYL)-4,5-ALPHA-EPOXY-3,14-DIHYDROXYMORPHINAN (CHLORANALTREXAMINE) - POTENT OPIOID RECEPTOR ALKYLATING AGENT WITH ULTRALONG NARCOTIC-ANTAGONIST ACTIVITY

被引：79

作者：

PORTOGHESE, PS ^{[1
]}

LARSON, DL ^{[1
]}

JIANG, JB ^{[1
]}

TAKEMORI, AE ^{[1
]}

CARUSO, TP ^{[1
]}

机构：

[1] UNIV MINNESOTA,SCH MED,DEPT PHARMACOL,MINNEAPOLIS,MN 55455

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1978年 / 21卷 / 07期

关键词：

D O I：

10.1021/jm00205a002

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：598 / 599

页数：2

共 19 条

[1] CYANOHYDRIDOBORATE ANION AS A SELECTIVE REDUCING AGENT [J].

BORCH, RF ;

BERNSTEIN, MD ;

DURST, HD .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1971, 93 (12) :2897-+

[2] STEREOSPECIFIC SYNTHESIS OF 6-BETA-HYDROXY METABOLITES OF NALTREXONE AND NALOXONE [J].

CHATTERJIE, N ;

INTURRISI, CE ;

DAYTON, HB ;

BLUMBERG, H .

JOURNAL OF MEDICINAL CHEMISTRY, 1975, 18 (05) :490-492

[3]

D'amour FE, 1941, J PHARMACOL EXP THER, V72, P74

[4] NARCOTIC-ANTAGONISTS .4. CARBON-6 DERIVATIVES OF N-SUBSTITUTED NOROXYMORPHONES AS NARCOTIC-ANTAGONISTS [J].

HAHN, EF ;

FISHMAN, J ;

HEILMAN, RD .

JOURNAL OF MEDICINAL CHEMISTRY, 1975, 18 (03) :259-262

[5] PHARMACOLOGICAL EFFECTS PRODUCED BY INTRACEREBRAL INJECTION OF DRUGS IN THE CONSCIOUS MOUSE [J].

HALEY, TJ ;

MCCORMICK, WG .

BRITISH JOURNAL OF PHARMACOLOGY AND CHEMOTHERAPY, 1957, 12 (01) :12-15

[6] STEREOCHEMICAL STUDIES ON MEDICINAL AGENTS .23. SYNTHESIS AND BIOLOGICAL EVALUATION OF 6-AMINO DERIVATIVES OF NALOXONE AND NALTREXONE [J].

JIANG, JB ;

HANSON, RN ;

PORTOGHESE, PS ;

TAKEMORI, AE .

JOURNAL OF MEDICINAL CHEMISTRY, 1977, 20 (08) :1100-1102

[7]

JULIUS D, 1976, NIDA9 RES MON

[8]

LITCHFIELD JT, 1949, J PHARMACOL EXP THER, V96, P99

[9] ANALGESIC HYPOTHERMIC AND DEPRESSANT ACTIVITIES OF SOME N-SUBSTITUTED ALPHA-5,9-DIMETHYL-6,7-BENZOMORPHANS [J].

MAY, M ;

CZONCHA, L ;

GARRISON, DR ;

TRIGGLE, DJ .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1968, 57 (05) :884-&

[10]

PASTERNAK GW, 1975, MOL PHARMACOL, V11, P340

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