LACK OF CROSS-PROTECTION BETWEEN VACCINIA VIRUS AND ORF VIRUS IN HYSTERECTOMY-PROCURED, BARRIER-MAINTAINED LAMBS

被引：19

作者：

MERCER, AA

YIRRELL, DL

REID, HW

ROBINSON, AJ

机构：

[1] MOREDUN ANIM RES INST,EDINBURGH,MIDLOTHIAN,SCOTLAND

[2] UNIV EDINBURGH,DEPT MED MICROBIOL,EDINBURGH,MIDLOTHIAN,SCOTLAND

来源：

VETERINARY MICROBIOLOGY | 1994年 / 41卷 / 04期

基金：

英国惠康基金;

关键词：

VACCINIA VIRUS; ORF VIRUS; SHEEP; VIRUS; CROSS-PROTECTION;

D O I：

10.1016/0378-1135(94)90033-7

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Hysterectomy-procured, barrier maintained lambs were immunised with either orf virus or vaccinia virus and subsequently challenged with both viruses. Under these conditions lambs were protected from challenge with the homologous virus but no cross-protection was observed. The feeding of colostrum that contained antibodies to orf virus had no effect on the duration of viral lesions. Immunoblotting analysis and ELISA of serum samples taken during the course of the experiment indicated that the animals mounted antibody responses to both viruses. The cross recognition of 3 vaccinia virus antigens by the hyperimmune anti-orf virus serum was revealed by immunoblotting.

引用

页码：373 / 382

页数：10

共 15 条

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