HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC PREPARATION OF OXYBUTYNIN ENANTIOMERS ON A CHIRAL STATIONARY-PHASE

被引：7

作者：

MIYAMOTO, E ^{[1
]}

DEMIZU, Y ^{[1
]}

MURATA, Y ^{[1
]}

YAMADA, Y ^{[1
]}

KAWASHIMA, S ^{[1
]}

KONTANI, H ^{[1
]}

SAKAI, T ^{[1
]}

机构：

[1] HOKURIKU UNIV,FAC PHARMACEUT SCI,DEPT PHARMACOL,KANAZAWA,ISHIKAWA 92011,JAPAN

来源：

JOURNAL OF CHROMATOGRAPHY A | 1993年 / 653卷 / 01期

关键词：

D O I：

10.1016/0021-9673(93)80401-S

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A method for the preparation of oxybutynin enantiomers by high-performance liquid chromatography (HPLC) on a chiral stationary phase (Chiralpak AD) was developed. Enantiomers were separated directly and rapidly without the need for any derivatization. Good optical resolution was obtained, with separation and resolution factors of 1.43 and 1.28, respectively. This method would be a useful alternative to synthetic preparation of the enantiomers.

引用

页码：135 / 137

页数：3

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