(CIS)-3-METHYL-1,5-BENZOTHIAZEPINE-4-ONES - POTENT ANALOGS OF THE CALCIUM-CHANNEL BLOCKER DILTIAZEM

被引：13

作者：

ATWAL, KS

AHMED, SZ

FLOYD, DM

MORELAND, S

HEDBERG, A

机构：

[1] Bristol-Myers Squibb, Pharmaceutical Research Institute, Princeton, NJ 08543

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 12期

关键词：

D O I：

10.1016/S0960-894X(01)80767-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

3-Methyl analogs of the calcium channel blocker diltiazem are reported. The title compounds were prepared from readily available amino thiophenols by a six step sequence which involves setting up the desired 2,3-cis-stereochemistry through decarboxylation under acidic conditions. To our knowledge, these are the most potent analogs of diltiazem reported to date.

引用

页码：2797 / 2800

页数：4

共 10 条

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