Targeting MAPK Signaling in Age-Related Macular Degeneration

被引:57
作者
Kyosseva, Svetlana V. [1 ]
机构
[1] Univ Arkansas Med Sci, Dept Biochem & Mol Biol, Little Rock, AR 72205 USA
来源
OPHTHALMOLOGY AND EYE DISEASES | 2016年 / 8卷
关键词
age-related macular degeneration; MAPK; ERK; JNK; p38; oxidative stress;
D O I
10.4137/OED.S32200
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Age-related macular degeneration (AMD) is a major cause of irreversible blindness affecting elderly people in the world. AMD is a-complex multifactorial disease associated with demographic, genetics, and environmental risk factors. It is well established that oxidative stress, inflammation, and apoptosis play critical roles in the pathogenesis of AMD. The mitogen-activated protein kinase (MAPK) signaling pathways are activated by diverse extracellular stimuli, including growth factors, mitogens, hormones, cytokines, and different cellular stressors such as oxidative stress. They regulate cell proliferation, differentiation, survival, and apoptosis. This review addresses the novel findings from human and animal studies on the relationship of MAPK signaling with AMD. The use of specific MAPK inhibitors may represent a potential therapeutic target for the treatment of this debilitating eye disease.
引用
收藏
页码:23 / 30
页数:8
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