SOMATOSTATIN RECEPTOR SUBTYPE SSTR2 MEDIATES THE INHIBITION OF HIGH-VOLTAGE-ACTIVATED CALCIUM CHANNELS BY SOMATOSTATIN AND ITS ANALOG SMS-201-995

被引：46
作者：
FUJII, Y
GONOI, T
YAMADA, Y
CHIHARA, K
INAGAKI, N
SEINO, S
机构：
[1] CHIBA UNIV,SCH MED,CTR BIOMED SCI,DIV MOLEC MED,CHUO KU,CHIBA 260,JAPAN
[2] CHIBA UNIV,PATHOGEN FUNGI & MICROBIAL TOXICOSES RES CTR,CHIBA 260,JAPAN
[3] KYOTO UNIV,SCH MED,DEPT METAB & CLIN NUTR,KYOTO 606,JAPAN
[4] KOBE UNIV,SCH MED,DEPT MED,DIV 3,KOBE 650,JAPAN
来源：
FEBS LETTERS | 1994年 / 355卷 / 02期
关键词：
SOMATOSTATIN ANALOG; SOMATOSTATIN RECEPTOR SUBTYPE; VOLTAGE-DEPENDENT CALCIUM CHANNEL; G-PROTEIN; INTRACELLULAR CALCIUM;
D O I：
10.1016/0014-5793(94)01159-1
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Somatostatin and its anologue SMS 201-995 inhibit high voltage-activated (HVA) Ca2+ currents in the rat insulinoma cell line RINm5F which stably express cloned human somatostatin receptor subtype 2 (hSSTR2). In contrast, neither somatostatin nor SMS 201-995 suppresses the HVA Ca2+ currents in RINm5F which stably express cloned hSSTR1. These results suggest that somatostatin-induced inhibition of HVA Ca2+ currents is mediated by a specific receptor subtype and that inhibition of calcium influx through HVA Ca2+ channels is one of the mechanisms of SMS 201-995 action on inhibitory processes of hormone secretion and cell proliferation.
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页码：117 / 120
页数：4
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