TRANSCRIPTION FACTOR TFIID RECOGNIZES DNA-SEQUENCES DOWNSTREAM OF THE TATA ELEMENT IN THE HSP70 HEAT-SHOCK GENE

被引：43

作者：

EMANUEL, PA

GILMOUR, DS

机构：

[1] Center for Gene Regulation, Dept. of Molecular and Cell Biology, Pennsylvania State University, University Park

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1993年 / 90卷 / 18期

关键词：

D O I：

10.1073/pnas.90.18.8449

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The interaction between the Hsp70 heat shock gene promoter and a Drosophila protein complex which contains the TATA-binding protein depends on sequence-specific interactions located in the region downstream of the transcription start site. Immunopurification of the complex through the use of antibodies against the TATA-binding protein reveals that the complex is transcription factor TFIID. Binding assays with the immunopurified TFIID confirm that sequence-specific contacts are made in the region between nucleotides +18 and +33 relative to the transcription start site. These sequence-specific interactions could play key roles in recognition of TATA-containing and TATA-less promoters.

引用

页码：8449 / 8453

页数：5

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