IMMUNOGENICITY OF INACTIVATED HEPATITIS-A VIRAL VACCINE OF CELL-CULTURE ORIGIN

被引：0

作者：

KUSOV, YY ^{[1
]}

ELBERT, LB ^{[1
]}

KAZACHKOV, YA ^{[1
]}

VALYANO, NM ^{[1
]}

NELGA, IV ^{[1
]}

GRISHINA, GK ^{[1
]}

KRUTYANSKAYA, GL ^{[1
]}

LISITSYNA, EA ^{[1
]}

POLESHCHUK, VF ^{[1
]}

SOBOL, AV ^{[1
]}

TITOVA, IP ^{[1
]}

KARPOVICH, LG ^{[1
]}

KALASHNIKOVA, TV ^{[1
]}

BALAYAN, MS ^{[1
]}

机构：

[1] LA TARASEVICH MED BIOL PREPARAT INST,MOSCOW,USSR

来源：

VOPROSY VIRUSOLOGII | 1991年 / 36卷 / 03期

关键词：

D O I：

暂无

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A trial of inactivated hepatitis A viral vaccine of heteroploid cell culture origin is described. The vaccine preparation was tested in guinea pigs and tamarins. The animals were immunized intramuscularly four or three times, respectively. The efficacy was judged by induction of anti-HAV antibody persisting for at least 12 months in guinea pigs, and development of immunity to subsequent virus challenge (monkeys only). The challenge dose of HAV was unable to produce any signs of HAV infection in the vaccinated tamarins, although the booster effect was observed in some animals. The study demonstrated that the tested batches of the vaccine were highly immunogenic.

引用

页码：206 / 209

页数：4

共 14 条

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[7] HEPATITIS-A VIRUS-REPLICATION IN TAMARINS AND HOST IMMUNE-RESPONSE IN RELATION TO PATHOGENESIS OF LIVER-CELL DAMAGE
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[8] KUSOV YY, 1991, VOP VIRUSOL, P156
[9] MIRONOVA LL, 1987, VOP VIRUSOL+, P740
[10] POLESHCHUK VF, 1982, VOPR VIRUSOL, P116

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