HEPATOCYTE RESPONSE TO CONTINUOUS LOW DOSE-RATE RADIATION IN RADIOIMMUNOTHERAPY ASSESSED BY MICRONUCLEUS ASSAY

被引：6

作者：

SAKAHARA, H ^{[1
]}

ONO, K ^{[1
]}

SAGA, T ^{[1
]}

AKUTA, K ^{[1
]}

ENDO, K ^{[1
]}

KONISHI, J ^{[1
]}

ABE, M ^{[1
]}

机构：

[1] KYOTO UNIV HOSP,DEPT RADIOL,KYOTO 606,JAPAN

来源：

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY | 1992年 / 62卷 / 04期

关键词：

D O I：

10.1080/09553009214552321

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The response of hepatocytes to low dose-rate irradiation was examined in mice following the injection of radiolabelled monoclonal antibody. Mice were injected intravenously with an I-131-labelled monoclonal antibody 196-14 which recognizes CA125 antigen, and the effect of continuous low dose-rate irradiation on hepatocytes was assessed using the micronucleus assay. The frequency of micronuclei increased in a dose-dependent fashion, but it was lower than the frequency induced by conventional external X-rays which was determined immediately after the irradiation. A linear quadratic model (micronucleus frequency = aD + bD2 + c) showed that the value of b decreased with low dose-rate irradiation from the radiolabelled antibody. It is concluded that the micronucleus assay is useful for the evaluation of the response of hepatocytes to irradiation in radioimmunotherapy.

引用

页码：443 / 448

页数：6

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