THE SYNTHESIS OF ORTHO-[F-18]FLUOROBENZYL AND PARA-[F-18]FLUOROBENZYL BROMIDES AND THEIR APPLICATION TO THE PREPARATION OF LABELED NEUROLEPTICS

被引：18

作者：

HATANO, K ^{[1
]}

IDO, T ^{[1
]}

IWATA, R ^{[1
]}

机构：

[1] TOHOKU UNIV,CYRIC,DIV RADIOPHARMACEUT CHEM,AOBA KU,SENDAI,MIYAGI 980,JAPAN

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 1991年 / 29卷 / 04期

关键词：

18F]ARYLFLUORIDE; POSITRON EMISSION TOMOGRAPHY; D2-DOPAMINE RECEPTOR;

D O I：

10.1002/jlcr.2580290403

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The syntheses of o- and p- [F-18]fluorobenzyl bromides as labeled synthons were described. They were obtained from nitrobenzaldehyde via a three step synthesis that exhibited good yield. The preparation of [F-18]fluororinated analog of a benzamide neuroleptic, cis-N-[(2RS, 3RS)-1-[F-18]fluorobenzyl-2-methyl-pyrrolidin-3-yl]-5-chloro-2-methoxy-4-methylaminobenzamide, via N-benzylation with the synthons was also mentioned.

引用

页码：373 / 380

页数：8

共 14 条

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