Mutations in ribosomal proteins: Apoptosis, cell competition, and cancer

被引：8
作者：
Baker, Nicholas E. [1 ,2 ,3 ]
Kale, Abhijit
机构：
[1] Albert Einstein Coll Med, Dept Genet, Bronx, NY 10467 USA
[2] Albert Einstein Coll Med, Dept Dev & Mol Biol, Bronx, NY 10467 USA
[3] Albert Einstein Coll Med, Dept Ophthalmol & Visual Sci, Bronx, NY 10467 USA
来源：
MOLECULAR & CELLULAR ONCOLOGY | 2016年 / 3卷 / 01期
关键词：
apoptosis; cancer predisposition; Drosophila melanogaster; genetic mosaic; ribosomal protein; somatic mutation;
D O I：
10.1080/23723556.2015.1029065
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Mutations affecting multiple ribosomal proteins are implicated in cancer. Using genetic mosaics in the fruit fly Drosophila, we describe 3 apoptotic mechanisms that affect Rp/Rp homozygous mutant cells, Rp/C heterozygous cells, or Rp/C heterozygous cells in competition with nearby wild type cells, and discuss how apoptosis might be related to cancer predisposition.
引用
收藏
页数：2
相关论文
共 10 条
[1]   Cell competition: how to eliminate your neighbours [J].
Amoyel, Marc ;
Bach, Erika A. .
DEVELOPMENT, 2014, 141 (05) :988-1000
[2]   Myc-driven endogenous cell competition in the early mammalian embryo [J].
Claveria, Cristina ;
Giovinazzo, Giovanna ;
Sierra, Rocio ;
Torres, Miguel .
NATURE, 2013, 500 (7460) :39-U53
[3]   CELL-PROLIFERATION IN CARCINOGENESIS [J].
COHEN, SM ;
ELLWEIN, LB .
SCIENCE, 1990, 249 (4972) :1007-1011
[4]   Exome sequencing identifies mutation in CNOT3 and ribosomal genes RPL5 and RPL10 in T-cell acute lymphoblastic leukemia [J].
De Keersmaecker, Kim ;
Atak, Zeynep Kalender ;
Li, Ning ;
Vicente, Carmen ;
Patchett, Stephanie ;
Girardi, Tiziana ;
Gianfelici, Valentina ;
Geerdens, Ellen ;
Clappier, Emmanuelle ;
Porcu, Michael ;
Lahortiga, Idoya ;
Luca, Rossella ;
Yan, Jiekun ;
Hulselmans, Gert ;
Vranckx, Hilde ;
Vandepoel, Roel ;
Sweron, Bram ;
Jacobs, Kris ;
Mentens, Nicole ;
Wlodarska, Iwona ;
Cauwelier, Barbara ;
Cloos, Jacqueline ;
Soulier, Jean ;
Uyttebroeck, Anne ;
Bagni, Claudia ;
Hassan, Bassem A. ;
Vandenberghe, Peter ;
Johnson, Arlen W. ;
Aerts, Stein ;
Cools, Jan .
NATURE GENETICS, 2013, 45 (02) :186-190
[5]  
Ebert RL, 2008, NATURE, V451, P335
[6]   Diamond Blackfan anemia: A disorder of red blood cell development [J].
Ellis, Steven R. ;
Lipton, Jeffrey M. .
RED CELL DEVELOPMENT, 2008, 82 :217-+
[7]   Apoptotic mechanisms during competition of ribosomal protein mutant cells: roles of the initiator caspases Dronc and Dream/Strica [J].
Kale, A. ;
Li, W. ;
Lee, C-H ;
Baker, N. E. .
CELL DEATH AND DIFFERENTIATION, 2015, 22 (08) :1300-1312
[8]   An ancient defense system eliminates unfit cells from developing tissues during cell competition [J].
Meyer, S. N. ;
Amoyel, M. ;
Bergantinos, C. ;
de la Cova, C. ;
Schertel, C. ;
Basler, K. ;
Johnston, L. A. .
SCIENCE, 2014, 346 (6214) :1199-+
[9]   Germline Mutation of RPS20, Encoding a Ribosomal Protein, Causes Predisposition to Hereditary Nonpolyposis Colorectal Carcinoma Without DNA Mismatch Repair Deficiency [J].
Nieminen, Taina T. ;
O'Donohue, Marie-Francoise ;
Wu, Yunpeng ;
Lohi, Hannes ;
Scherer, Stephen W. ;
Paterson, Andrew D. ;
Ellonen, Pekka ;
Abdel-Rahman, Wael M. ;
Valo, Satu ;
Mecklin, Jukka-Pekka ;
Jarvinen, Heikki J. ;
Gleizes, Pierre-Emmanuel ;
Peltomaki, Paivi .
GASTROENTEROLOGY, 2014, 147 (03) :595-+
[10]   Apoptosome Structure, Assembly, and Procaspase Activation [J].
Yuan, Shujun ;
Akey, Christopher W. .
STRUCTURE, 2013, 21 (04) :501-515
1