SPECIFIC VESICULAR ACETYLCHOLINE TRANSPORTER PROMOTERS LIE WITHIN THE FIRST INTRON OF THE RAT CHOLINE-ACETYLTRANSFERASE GENE

被引：75

作者：

CERVINI, R ^{[1
]}

HOUHOU, L ^{[1
]}

PRADAT, PF ^{[1
]}

BEJANIN, S ^{[1
]}

MALLET, J ^{[1
]}

BERRARD, S ^{[1
]}

机构：

[1] GRP HOSP PITIE SALPETRIERE, GENET MOLEC NEUROTRANSMISS & PROC NEURODEGENERAT, BATIMENT CERVI, F-75651 PARIS 13, FRANCE

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 1995年 / 270卷 / 42期

关键词：

D O I：

10.1074/jbc.270.42.24654

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The sequence encoding the vesicular acetylcholine transporter (VAChT) has recently been localized within the first intron of the choline acetyltransferase (ChAT) gene in various species. In rat, we previously identified a class of VAChT mRNAs that may originate from the same promoter region as two ChAT mRNAs. Here, we demonstrate by a detailed analysis of the 5'-noncoding region of the VAChT gene, that two specific VAChT promoters lie within the first intron of the ChAT gene. Two VAChT mRNAs are generated from these promoters. These results demonstrate that the promoter regions of these two genes are intermingled, which highlight the unique organization of the ChaT/VAChT gene locus.

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页码：24654 / 24657

页数：4

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