Isolation and characterization of cancer stem cells in renal cell carcinoma

被引：15
作者：
Lucarelli, Giuseppe [1 ]
Galleggiante, Vanessa [1 ]
Rutigliano, Monica [1 ]
Vavallo, Antonio [1 ]
Ditonno, Pasquale [1 ]
Battaglia, Michele [1 ]
机构：
[1] Univ Bari, Dept Emergency & Organ Transplantat Urol, Androl & Kidney Transplantat Unit, Bari, Italy
来源：
UROLOGIA JOURNAL | 2015年 / 82卷 / 01期
关键词：
CD133; CTR2; Kidney injury; Renal cell carcinoma; Stem cells;
D O I：
10.5301/uro.5000099
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Recently, several studies have investigated the presence of cancer stem cells in kidney cancer, performed characterization, and compared their profile with the normal stem cell counterparts. CD133, alone or in combination with other molecular markers, has been used to isolate normal and cancer stem cells from different sources, including renal carcinoma; however, it is still a matter of debate whether CD133+ cells really represent the main tumorigenic population within the heterogeneous pool of cancer cells that characterize this tumor. In this review, we summarize and discuss the current findings related to cancer stem cells isolation in renal cell carcinoma, focusing on controversies about their origin and the identification of a specific marker.
引用
收藏
页码：46 / 53
页数：8
相关论文
共 75 条
[1]   Characterization of the Hoechst 33342 side population from normal and malignant human renal epithelial cells [J].
Addla, Sanjai K. ;
Brown, Mick D. ;
Hart, Claire A. ;
Ramani, Vijay A. C. ;
Clarke, Noel W. .
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2008, 295 (03) :F680-F687
[2]   Prospective identification of tumorigenic breast cancer cells [J].
Al-Hajj, M ;
Wicha, MS ;
Benito-Hernandez, A ;
Morrison, SJ ;
Clarke, MF .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (07) :3983-3988
[3]   The apoptotic signaling pathway activated by Toll-like receptor-2 [J].
Aliprantis, AO ;
Yang, RB ;
Weiss, DS ;
Godowski, P ;
Zychlinsky, A .
EMBO JOURNAL, 2000, 19 (13) :3325-3336
[4]   Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2 [J].
Aliprantis, AO ;
Yang, RB ;
Mark, MR ;
Suggett, S ;
Devaux, B ;
Radolf, JD ;
Klimpel, GR ;
Godowski, P ;
Zychlinsky, A .
SCIENCE, 1999, 285 (5428) :736-739
[5]   Characterization of Renal Progenitors Committed Toward Tubular Lineage and Their Regenerative Potential in Renal Tubular Injury [J].
Angelotti, Maria Lucia ;
Ronconi, Elisa ;
Ballerini, Lara ;
Peired, Anna ;
Mazzinghi, Benedetta ;
Sagrinati, Costanza ;
Parente, Eliana ;
Gacci, Mauro ;
Carini, Marco ;
Rotondi, Mario ;
Fogo, Agnes B. ;
Lazzeri, Elena ;
Lasagni, Laura ;
Romagnani, Paola .
STEM CELLS, 2012, 30 (08) :1714-1725
[6]   Differentiation Therapy: Targeting Human Renal Cancer Stem Cells with Interleukin 15 [J].
Azzi, Sandy ;
Bruno, Stefania ;
Giron-Michel, Julien ;
Clay, Denis ;
Devocelle, Aurore ;
Croce, Michela ;
Ferrini, Silvano ;
Chouaib, Salem ;
Vazquez, Aime ;
Charpentier, Bernard ;
Camussi, Giovanni ;
Azzarone, Bruno ;
Eid, Pierre .
JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2011, 103 (24) :1884-1898
[7]   Hypoxia Increases the Expression of Stem-Cell Markers and Promotes Clonogenicity in Glioblastoma Neurospheres [J].
Bar, Eli E. ;
Lin, Alex ;
Mahairaki, Vasiliki ;
Matsui, William ;
Eberhart, Charles G. .
AMERICAN JOURNAL OF PATHOLOGY, 2010, 177 (03) :1491-1502
[8]   CD133+ and CD133- glioblastoma-derived cancer stem cells show differential growth characteristics and molecular profiles [J].
Beier, Dagmar ;
Hau, Peter ;
Proescholdt, Martin ;
Lohmeier, Annette ;
Wischhusen, Joerg ;
Oefner, Peter J. ;
Aigner, Ludwig ;
Brawanski, Alexander ;
Bogdahn, Ulrich ;
Beier, Christoph P. .
CANCER RESEARCH, 2007, 67 (09) :4010-4015
[9]   Ctr2 is partially localized to the plasma membrane and stimulates copper uptake in COS-7 cells [J].
Bertinato, Jesse ;
Swist, Eleonora ;
Plouffe, Louise J. ;
Brooks, Stephen P. J. ;
L'Abbe, Mary R. .
BIOCHEMICAL JOURNAL, 2008, 409 (03) :731-740
[10]   Copper Transporter 2 Regulates Endocytosis and Controls Tumor Growth and Sensitivity to Cisplatin In Vivo [J].
Blair, Brian G. ;
Larson, Christopher A. ;
Adams, Preston L. ;
Abada, Paolo B. ;
Pesce, Catherine E. ;
Safaei, Roohangiz ;
Howell, Stephen B. .
MOLECULAR PHARMACOLOGY, 2011, 79 (01) :157-166
12345678