PEROXIDASE-DEPENDENT METAL-INDEPENDENT OXIDATION OF LOW-DENSITY-LIPOPROTEIN IN-VITRO - A MODEL FOR IN-VIVO OXIDATION

被引：94

作者：

WIELAND, E ^{[1
]}

PARTHASARATHY, S ^{[1
]}

STEINBERG, D ^{[1
]}

机构：

[1] UNIV CALIF SAN DIEGO,DEPT MED,DIV ENDOCRINOL & METAB,LA JOLLA,CA 92093

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1993年 / 90卷 / 13期

关键词：

D O I：

10.1073/pnas.90.13.5929

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Oxidative modification of low density lipoprotein is believed to be an important pathway by which the lipoprotein becomes atherogenic. The in vitro systems for oxidative modification of low density lipoprotein thus far described all appear to depend upon the presence in the medium of free transition metal ions (copper or iron). In vivo, on the other hand, these metals are present almost exclusively in tightly complexed forms that do not catalyze oxidative modification. The present studies describe oxidation of low density lipoprotein in a simple system that does not depend upon the presence of added free metal ions. It requires the presence of horseradish peroxidase and either hydrogen peroxide or lipid hydroperoxides.

引用

页码：5929 / 5933

页数：5

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