ACANTHOSIS NIGRICANS AND HYPERANDROGENISM IN A PREGNANCY COMPLICATED BY DIABETES

Background: Acanthosis nigricans and hyperandrogenism have been associated with diabetes mellitus accompanied by insulin resistance. However, these manifestations have rarely been reported to occur as a result of the insulin resistance of pregnancy. Case: A 31-year-old woman with diabetes mellitus exhibited severe insulin resistance during pregnancy. At 32 weeks, daily administration of 500 U insulin was required to maintain glycemic control. Skin lesions typical of acanthosis nigricans appeared, and free testosterone levels were elevated (10.3 pg/mL). These manifestations resolved after delivery. Conclusion: This case may demonstrate a correlation between reversible gestational insulin resistance and acanthosis nigricans.