A COMPARISON OF THE HEURISTIC EVOLVING LATENT PROJECTIONS AND EVOLVING FACTOR-ANALYSIS METHODS FOR PEAK PURITY CONTROL IN LIQUID-CHROMATOGRAPHY WITH PHOTODIODE ARRAY DETECTION

被引：39
作者：
KELLER, HR [1 ]
MASSART, DL [1 ]
LIANG, YZ [1 ]
KVALHEIM, OM [1 ]
机构：
[1] UNIV BERGEN,DEPT CHEM,N-5007 BERGEN,NORWAY
来源：
ANALYTICA CHIMICA ACTA | 1992年 / 267卷 / 01期
关键词：
LIQUID CHROMATOGRAPHY; HEURISTIC EVOLVING LATENT PROJECTIONS; PEAK PURITY CONTROL; EVOLVING FACTOR ANALYSIS;
D O I：
10.1016/0003-2670(92)85007-S
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
The performance of the heuristic evolving latent projections (HELP) method is investigated for peak purity control in liquid chromatography with photodiode array detection. HELP and evolving factor analysis performed equally well; both techniques could detect less than 1% of a spectrally similar impurity even for small chromatographic separations. In certain cases, the two techniques may be limited by instrumental and experimental difficulties.
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页码：63 / 71
页数：9
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