THE POSTANTIBIOTIC SUPPRESSIVE EFFECT OF L-OFLOXACIN, AN OPTICALLY-ACTIVE ISOMER OF OFLOXACIN

被引:11
作者
FU, KP
FOLENO, B
ROSENTHALE, ME
机构
[1] R.W. Johnson Pharmaceutical Institute, Raritan, NJ
关键词
D O I
10.1016/0732-8893(92)90028-R
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
The postantibiotic suppressive effect (PAE) Of L-ofloxacin was studied and compared with those of ciprofloxacin and norfloxacin. The PAE of L-ofloxacin was observed against all Gram-positive organisms tested: Staphylococcus aureus, S. epidermidis, and Enterococcus faecalis. At the achievable serum concentrations L-ofloxacin showed a longer PAE than ciprofloxacin and norfloxacin. Exposure of organisms to 4-mu-g/ml of L-ofloxacin for 2 hr produced a 3.1 and 4.2 hr PAE for methicillin-sensitive and methicillin-resistant staphylococci, respectively. Against E. faecalis and S. epidermidis, the PAEs of L-ofloxacin were 1.9 and 1.6 hr, respectively.
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页码:375 / 378
页数:4
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