GENETIC-LINKAGE IS EXCLUDED FOR THE D2-DOPAMINE RECEPTOR LAMBDA-HD2G1 AND FLANKING LOCI ON CHROMOSOME 11Q22-Q23 IN TOURETTE SYNDROME

被引：36
作者：
DEVOR, EJ
GRANDY, DK
CIVELLI, O
LITT, M
BURGESS, AK
ISENBERG, KE
VANDEWETERING, BJM
OOSTRA, B
机构：
[1] OREGON HLTH SCI UNIV,VOLLUM INST ADV BIOMED RES,PORTLAND,OR 97201
[2] OREGON HLTH SCI UNIV,DEPT MED GENET & BIOCHEM,PORTLAND,OR 97201
[3] ERASMUS UNIV,DEPT CLIN GENET,3000 DR ROTTERDAM,NETHERLANDS
来源：
HUMAN HEREDITY | 1990年 / 40卷 / 02期
关键词：
Chromosome; 11q; Linkage; Tourette syndrome;
D O I：
10.1159/000153914
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
A genetic linkage study of fifteen families (n = 166) ascertained through probands diagnosed for Tourette syndrome was carried out for the D2dopamine receptor and flanking loci on chromosome 11q22-q23. Tight linkage was excluded for all probes and regions of exclusion up to ±20% recombination were obtained. Overlapping regions of exclusion based upon primary map data permit exclusion of the entire region of the DRD2 locus in Tourette syndrome. © 1990 S. Karger AG, Basel.
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页码：105 / 108
页数：4
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