METABOLISM OF TRITIATED DOPAMINE IN REGIONS OF RAT BRAIN IN VIVO .I. SEPARATION OF CATECHOLAMINES AND THEIR METABOLITES

被引：82
作者：
TAYLOR, KM
LAVERTY, R
机构：
[1] Wellcome Medical Research Institute, Department of Medicine, University of Otago Medical School, Dunedin
来源：
JOURNAL OF NEUROCHEMISTRY | 1969年 / 16卷 / 09期
关键词：
D O I：
10.1111/j.1471-4159.1969.tb05987.x
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Abstract— A simple combination of acid‐ and base‐exchange resin columns enabled a more complete separation of amine, acid and neutral metabolites of catecholamines from individual small brain samples to be made. Fractions containing individual catecholamines or metabolites were obtained in aqueous eluates suitable for fluorimetric or radioisotopic analysis. With consistent intraventricular injection and brain dissection techniques, this separation method enables a study of the metabolism of catecholamines in regions of the rat brain and the effects of drugs on this metabolism. Copyright © 1969, Wiley Blackwell. All rights reserved
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页码：1361 / &
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