A PROSPECTIVE EVALUATION OF TL-201 SINGLE-PHOTON EMISSION COMPUTERIZED-TOMOGRAPHY FOR BRAIN-TUMOR BURDEN

被引：28
作者：
LORBERBOYM, M
BARAM, J
FEIBEL, M
HERCBERGS, A
LIEBERMAN, L
机构：
[1] CHAIM SHEBA MED CTR,DEPT NUCL MED,TEL HASHOMER,ISRAEL
[2] CHAIM SHEBA MED CTR,DEPT ONCOL,TEL HASHOMER,ISRAEL
[3] CHAIM SHEBA MED CTR,DEPT RADIOL,TEL HASHOMER,ISRAEL
[4] TEL AVIV UNIV,SACKLER SCH MED,IL-69978 TEL AVIV,ISRAEL
来源：
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS | 1995年 / 32卷 / 01期
关键词：
BRAIN NEOPLASMS; RADIONUCLIDE DIAGNOSIS; TL-201; SPECT; CT; GLIOBLASTOMA; ASTROCYTOMA;
D O I：
10.1016/0360-3016(95)00580-R
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Purpose: The follow-up of patients with malignant brain tumors after surgery, radiation, and/or chemotherapy has been inadequate for evaluating brain tumor burden using computerized tomography (CT) or magnetic resonance imaging(MRI). Thallium-201 has been shown to concentrate in viable tumor, and Tl-201 single photon emission computerized tomography (SPECT) imaging can identify tumor burden more accurately than CT. Methods and Materials: Thirty-one patients with glioblastoma and three patients with low grade astrocytoma were studied with Tl-201 SPECT, Histololgic diagnosis was obtained in all patients by biopsy and all patients had CT scans within 2 weeks of the SPECT study, Seventeen patients were followed with one or more SPECT and CT evaluations. Results: Single photon emission computerized tomography studies, after surgery, radiotherapy, and/or chemotherapy, were more accurate than CT in identifying progression or regression of disease, Twenty-three patients had evidence of disease and 11 patients had no evidence of recurrent disease in the initial Tl-201 SPECT study following therapy, Computerized tomography identified 20 of the 23 patients with disease and 6 of 11 patients with no recurrent disease. Follow-up with Tl-201 SPECT in 17 patients suggested progression of disease in 9 patients, while CT showed progression in only 3 patients, Clinical examinations and repeat CT studies confirmed the accuracy of Tl-201 SPECT images. Conclusion: We found Tl-201 SPECT more accurate than CT scans in a prospective evaluation of 34 patients with brain tumor, Follow-up studies with both Tl-201 SPECT and CT imaging in 17 patients demonstrated that SPECT was more reliable than CT in identifying progression, improvement, or no change in brain tumor burden.
引用
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页码：249 / 254
页数：6
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