RAPID AND SENSITIVE DETERMINATION OF PIROXICAM IN RAT PLASMA, MUSCLE AND SKIN BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY

被引：24
|
作者：
CERRETANI, D
MICHELI, L
FIASCHI, AI
GIORGI, G
机构：
[1] Institute of Pharmacology, University of Siena, 53100 Siena
来源：
JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1993年 / 614卷 / 01期
关键词：
D O I：
10.1016/0378-4347(93)80228-V
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A rapid and precise high-performance liquid chromatographic method for the determination of piroxicam in a variety of biological samples has been developed. A reversed-phase column, isocratic elution and ultraviolet detection were employed. Calibration curves were reproducible and highly linear, with correlation coefficients typically averaging over 0.992. The detection limit of the assay was 100 ng/ml for all biological samples examined (at a signal-to-noise ratio of 3:1). Validation of the method demonstrated a good sensitivity, accuracy and precision. The method has been adopted for a pharmacokinetic study in rats.
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页码：103 / 108
页数：6
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