INVIVO SISTER-CHROMATID EXCHANGE - SENSITIVE MEASURE OF DNA DAMAGE

被引：123
作者：
NAKANISHI, Y
SCHNEIDER, EL
机构：
来源：
MUTATION RESEARCH | 1979年 / 60卷 / 03期
关键词：
D O I：
10.1016/0027-5107(79)90023-X
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
A variety of chemical agents and X-irradiation were examined for their abilities to induced sister-chromatid exchanges (SCE) in vivo. In addition to demonstrating the several known mutagens and carcinogens are capable of inducing SCE in vivo, our studies indicate that the suspected carcinogen, tris-bromophosphate, can significantly elevate SCE levels. Comparison of the effects of these agents on SCE levels, chromosomal-aberration frequencies and cell-replication kinetics reveals that no consistent relationship exists between SCE levels and other indicators of cellular DNA damage. It is proposed that analysis of SCE induction in vivo may provide a useful technique for the screening of mutagenic and carcinogenic compounds. © 1979.
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页码：329 / 337
页数：9
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