SEVERE HEMOLYTIC-ANEMIA DUE TO COLD ANTI-I ANTIBODIES ASSOCIATED WITH CYTOMEGALOVIRUS-INFECTION

被引：7
作者：
AGUADO, JM
CASTRILLO, JM
SANZ, J
SERRANO, J
机构：
[1] FDN JIMENEZ DIAZ,DEPT INTERNAL MED,MADRID,SPAIN
[2] FDN JIMENEZ DIAZ,DEPT HEMATOL,MADRID,SPAIN
来源：
POSTGRADUATE MEDICAL JOURNAL | 1990年 / 66卷 / 775期
关键词：
D O I：
10.1136/pgmj.66.775.392
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
A 66 year old patient with multiple myeloma and monoclonal cryoglobulinaemia who developed a severe haemolytic anaemia following a cytomegalovirus infection is reported. The presence of a high titre of anti-'i' cold antibody of IgM subclass is demonstrated. Anti-'i' antibody disappeared when complement-fixation antibody titres against cytomegalovirus decreased. Various pathogenetic mechanisms involved in the development of haemolytic anaemia associated with cytomegalovirus infection are discussed. To our knowledge, this is the first case described in the English language publications associating severe haemolytic anaemia with an anti-'i' antibody after a cytomegalovirus infection in an immunocompromised patient.
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页码：392 / 394
页数：3
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